Literature DB >> 16271499

Epstein-Barr virus: inhibition of apoptosis as a mechanism of cell transformation.

Michael J Clemens1.   

Abstract

Epstein-Barr virus is a potent mitogen for human B lymphocytes and is associated with a large number of human malignancies. This large virus expresses several genes that may contribute to the transformed phenotype of infected cells and it possesses multiple strategies for the inhibition of apoptosis. The interferon-inducible protein kinase PKR is an important target for the anti-apoptotic actions of the virus and its activity is regulated by the small untranslated RNA, EBER-1. This review summarizes the mechanisms of action of EBER-1 and other Epstein-Barr virus gene products in the regulation of apoptosis, and presents a model of how EBER-1 exerts its effects on PKR activity.

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Year:  2005        PMID： 16271499     DOI： 10.1016/j.biocel.2005.09.014

Source DB:  PubMed          Journal:  Int J Biochem Cell Biol        ISSN： 1357-2725            Impact factor:   5.085


  7 in total

Review 1.  Staying alive: bacterial inhibition of apoptosis during infection.

Authors:  Christina S Faherty; Anthony T Maurelli
Journal:  Trends Microbiol       Date:  2008-03-18       Impact factor: 17.079

2.  p53 and hTERT determine sensitivity to viral apoptosis.

Authors:  Marie L Nguyen; Rachel M Kraft; Martine Aubert; Edward Goodwin; Daniel DiMaio; John A Blaho
Journal:  J Virol       Date:  2007-09-12       Impact factor: 5.103

3.  Lymphoid hyperplasia and lymphoma in transgenic mice expressing the small non-coding RNA, EBER1 of Epstein-Barr virus.

Authors:  Claire E Repellin; Penelope M Tsimbouri; Adrian W Philbey; Joanna B Wilson
Journal:  PLoS One       Date:  2010-02-08       Impact factor: 3.240

4.  Antiapoptotic activity of the cardiovirus leader protein, a viral "security" protein.

Authors:  Lyudmila I Romanova; Peter V Lidsky; Marina S Kolesnikova; Ksenia V Fominykh; Anatoly P Gmyl; Eugene V Sheval; Stanleyson V Hato; Frank J M van Kuppeveld; Vadim I Agol
Journal:  J Virol       Date:  2009-05-06       Impact factor: 5.103

Review 5.  Impact of protein kinase PKR in cell biology: from antiviral to antiproliferative action.

Authors:  M A García; J Gil; I Ventoso; S Guerra; E Domingo; C Rivas; M Esteban
Journal:  Microbiol Mol Biol Rev       Date:  2006-12       Impact factor: 11.056

Review 6.  Apoptosis, Autophagy, and Pyroptosis: Immune Escape Strategies for Persistent Infection and Pathogenesis of Classical Swine Fever Virus.

Authors:  Sheng-Ming Ma; Qian Mao; Lin Yi; Ming-Qiu Zhao; Jin-Ding Chen
Journal:  Pathogens       Date:  2019-11-16

Review 7.  Viral strategies to subvert the mammalian translation machinery.

Authors:  Lisa O Roberts; Catherine L Jopling; Richard J Jackson; Anne E Willis
Journal:  Prog Mol Biol Transl Sci       Date:  2009-10-27       Impact factor: 3.622
  7 in total

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