| Literature DB >> 16271472 |
Katja Strancar1, Didier Blanot, Stanislav Gobec.
Abstract
A series of new phosphinate compounds were designed and synthesized as inhibitors of the d-glutamic acid-adding enzyme (MurD) involved in peptidoglycan biosynthesis. They were tested against the MurD enzyme from Escherichia coli, allowing initial structure-activity relationships to be deduced. Two compounds had IC(50) values near 100 microM and constitute a promising starting point for further development.Entities:
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Year: 2005 PMID： 16271472 DOI： 10.1016/j.bmcl.2005.09.086
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823