Literature DB >> 16270665

New trends in synthesis of pyrazole nucleosides as new antimetabolites.

Galal H Elgemeie1, Wafaa A Zaghary, Kamelia M Amin, Tamer M Nasr.   

Abstract

Pyrazole nucleosides and condensed pyrazole nucleosides exhibit various biological activities. This article describes recent synthetic approaches to their preparation, chemical properties, biological activities, and structure-activity relationships, with emphasis to selected drugs or drug candidates. Two pyrazole C-nucleoside compounds pyrazofurin (pyrazomycin) and its alpha-epimer pyrazofurin B are active components of potent antivirals approved for therapeutic use in human medicine aimed against various diseases caused by DNA viruses.

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Year:  2005        PMID： 16270665     DOI： 10.1081/NCN-200067421

Source DB:  PubMed          Journal:  Nucleosides Nucleotides Nucleic Acids        ISSN： 1525-7770            Impact factor:   1.381


  3 in total

1.  Structural determinants for the inhibitory ligands of orotidine-5'-monophosphate decarboxylase.

Authors:  Maria Elena Meza-Avina; Lianhu Wei; Yan Liu; Ewa Poduch; Angelica M Bello; Ram K Mishra; Emil F Pai; Lakshmi P Kotra
Journal:  Bioorg Med Chem       Date:  2010-04-09       Impact factor: 3.641

2.  Crystal structure of 4-{[(cyano-imino)(methyl-sulfanyl)meth-yl]amino}-1,5-dimethyl-2-phenyl-2,3-di-hydro-1H-pyrazol-3-one.

Authors:  Galal H Elgemeie; Mamdouh Abouzeid; Peter G Jones
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2015-01-01

3.  DFT, Monte Carlo and molecular dynamics simulations for the prediction of corrosion inhibition efficiency of novel pyrazolylnucleosides on Cu(111) surface in acidic media.

Authors:  Rachid Oukhrib; Youness Abdellaoui; Avni Berisha; Hicham Abou Oualid; Jeton Halili; Kaltrina Jusufi; Mustapha Ait El Had; Hassan Bourzi; Souad El Issami; Fatmah Ali Asmary; Virinder S Parmar; Christophe Len
Journal:  Sci Rep       Date:  2021-02-12       Impact factor: 4.379
  3 in total

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