Literature DB >> 16270661

Synthesis of phosphonate analogues of the antiviral cyclopropane nucleoside A-5021.

Tomoyuki Onishi1, Takaaki Sekiyama, Takashi Tsuji.   

Abstract

A series of phosphonate analogues of the antiviral cyclopropane nucleoside A-5021 were synthesized from (1S*, 7R*)-3,5-dioxa-4,4-diphenylbicyclo[5. 1.0]octane-l-methanol by a 10-step process. In contrast to the potent antiherpetic activity of A-5021, they were all devoid of antiviral activity.

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Year:  2005        PMID: 16270661     DOI: 10.1081/NCN-200067409

Source DB:  PubMed          Journal:  Nucleosides Nucleotides Nucleic Acids        ISSN: 1525-7770            Impact factor:   1.381


  1 in total

1.  Antiviral activities of novel 5-phosphono-pent-2-en-1-yl nucleosides and their alkoxyalkyl phosphonoesters.

Authors:  Hyunah Choo; James R Beadle; Earl R Kern; Mark N Prichard; Kathy A Keith; Caroll B Hartline; Julissa Trahan; Kathy A Aldern; Brent E Korba; Karl Y Hostetler
Journal:  Antimicrob Agents Chemother       Date:  2006-11-27       Impact factor: 5.191

  1 in total

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