AIM: To evaluate the agreement between a mAb-based stool test (HP StAR) and the urea breath test (UBT) in monitoring (H pylori) infection after eradication therapy. METHODS: Patients with discordant results on UBT and Hp StAR underwent endoscopy with biopsies for rapid urease test, culture, and histology to confirm H pylori status. RESULTS: Among 250 patients (50+/-14 years), 240 (96.0%) had concordant UBT and Hp StAR tests with a significant correlation between DOB and A values (R = 0.87; P<0.0001). The remaining 10 (4.0%) patients had discordant tests (positive Hp StAR and negative UBT) with the Hp StAR inaccurate in five cases (false positive) and UBT inaccurate in the other five cases (false negative). The "maximal expected" sensitivity, specificity, +PV, -PV, +LR, and -LR were 91%, 100%, 100%, 97.4%, infinity, and 8.2 respectively, for the UBT, and 100%, 97.4%, 91%, 100%, 38.8, and 0, respectively, for the Hp StAR. Overall accuracy for both tests was 98%. CONCLUSION: Both the UBT and the Hp StAR are equally accurate in monitoring H pylori infection. Nowadays, the choice of the "best" non-invasive H pylori test in the post-treatment setting should be done not only in terms of diagnostic accuracy but also in view of cost and local facilities.
AIM: To evaluate the agreement between a mAb-based stool test (HP StAR) and the urea breath test (UBT) in monitoring (H pylori) infection after eradication therapy. METHODS:Patients with discordant results on UBT and Hp StAR underwent endoscopy with biopsies for rapid urease test, culture, and histology to confirm H pylori status. RESULTS: Among 250 patients (50+/-14 years), 240 (96.0%) had concordant UBT and Hp StAR tests with a significant correlation between DOB and A values (R = 0.87; P<0.0001). The remaining 10 (4.0%) patients had discordant tests (positive Hp StAR and negative UBT) with the Hp StAR inaccurate in five cases (false positive) and UBT inaccurate in the other five cases (false negative). The "maximal expected" sensitivity, specificity, +PV, -PV, +LR, and -LR were 91%, 100%, 100%, 97.4%, infinity, and 8.2 respectively, for the UBT, and 100%, 97.4%, 91%, 100%, 38.8, and 0, respectively, for the Hp StAR. Overall accuracy for both tests was 98%. CONCLUSION: Both the UBT and the Hp StAR are equally accurate in monitoring H pylori infection. Nowadays, the choice of the "best" non-invasive H pylori test in the post-treatment setting should be done not only in terms of diagnostic accuracy but also in view of cost and local facilities.
Authors: F Luzza; M Imeneo; A Marasco; S Crotta; E Ierardi; P Usai; C Virgilio; G Nardone; S Marchi; G Sanna; F Perri; R Maurizio Zagari; F Bazzoli Journal: Eur J Gastroenterol Hepatol Date: 2000-10 Impact factor: 2.566
Authors: D Vaira; P Malfertheiner; F Mégraud; A T Axon; M Deltenre; A M Hirschl; G Gasbarrini; C O'Morain; J M Garcia; M Quina; G N Tytgat Journal: Lancet Date: 1999-07-03 Impact factor: 79.321
Authors: V Ellenrieder; B Glasbrenner; C Stoffels; S Weiler; G Bode; P Möller; G Adler Journal: Eur J Gastroenterol Hepatol Date: 1997-11 Impact factor: 2.566
Authors: A Zullo; D Vaira; N Vakil; C Hassan; L Gatta; C Ricci; V De Francesco; M Menegatti; A Tampieri; F Perna; V Rinaldi; F Perri; C Papadìa; F Fornari; S Pilati; L S Mete; A Merla; R Potì; G Marinone; A Savioli; S M A Campo; D Faleo; E Ierardi; M Miglioli; S Morini Journal: Aliment Pharmacol Ther Date: 2003-03-01 Impact factor: 8.171
Authors: J P Gisbert; M Trapero; X Calvet; J Mendoza; M Quesada; M Güell; J M Pajares Journal: Aliment Pharmacol Ther Date: 2004-04-15 Impact factor: 8.171
Authors: L Gatta; F Perna; C Ricci; J F Osborn; A Tampieri; V Bernabucci; M Miglioli; D Vaira Journal: Aliment Pharmacol Ther Date: 2004-08-15 Impact factor: 8.171