PURPOSE/ OBJECTIVES: To review the domains of cognitive function and their corresponding neuroanatomic structures as well as present current evidence for neurotoxicity associated with specific chemotherapeutic agents and potential mechanisms for chemotherapy-induced cognitive impairments. DATA SOURCES: Published research articles, review articles, and textbooks. DATA SYNTHESIS: Chemotherapy does not appear to cross the blood-brain barrier when given in standard doses; however, many chemotherapy drugs have the potential to cause cognitive impairments through more than one mechanism. In addition, patient factors may be protective or place individuals at higher risk for cognitive impairments. CONCLUSIONS: Although evidence of chemotherapy-induced impairments in cognitive function exists, no clinical studies have attempted to elucidate the mechanisms for chemotherapy-induced impairments in cognitive function. In addition, further studies are needed to determine predictive factors, potential biomarkers, and relevant assessment parameters. IMPLICATIONS FOR NURSING: The ability to identify high-risk patients has important implications for practice in regard to informed consent, patient education about the effects of treatment, and preventive strategies.
PURPOSE/ OBJECTIVES: To review the domains of cognitive function and their corresponding neuroanatomic structures as well as present current evidence for neurotoxicity associated with specific chemotherapeutic agents and potential mechanisms for chemotherapy-induced cognitive impairments. DATA SOURCES: Published research articles, review articles, and textbooks. DATA SYNTHESIS: Chemotherapy does not appear to cross the blood-brain barrier when given in standard doses; however, many chemotherapy drugs have the potential to cause cognitive impairments through more than one mechanism. In addition, patient factors may be protective or place individuals at higher risk for cognitive impairments. CONCLUSIONS: Although evidence of chemotherapy-induced impairments in cognitive function exists, no clinical studies have attempted to elucidate the mechanisms for chemotherapy-induced impairments in cognitive function. In addition, further studies are needed to determine predictive factors, potential biomarkers, and relevant assessment parameters. IMPLICATIONS FOR NURSING: The ability to identify high-risk patients has important implications for practice in regard to informed consent, patient education about the effects of treatment, and preventive strategies.
Authors: Jill E Macleod; Joyce A DeLeo; William F Hickey; Tim A Ahles; Andrew J Saykin; David J Bucci Journal: Behav Brain Res Date: 2007-04-19 Impact factor: 3.332
Authors: Camille C Gunderson; Adam C Walter; Rachel Ruskin; Kai Ding; Kathleen N Moore Journal: Support Care Cancer Date: 2016-06-15 Impact factor: 3.603
Authors: Karin Olson; A Robert Turner; Kerry S Courneya; Catherine Field; Godfrey Man; Marilyn Cree; John Hanson Journal: Support Care Cancer Date: 2007-07-24 Impact factor: 3.603