BACKGROUND: This pilot study investigated the feasibility of (18)F-3'-deoxy-3'-fluoro-l-thymidine ((18)F-FLT) as a positron emission tomography (PET) tracer for the visualisation of breast cancer. METHODS: Patients with breast cancer underwent (18)F-FLT-PET prior to surgery. The uptake of (18)F-FLT was determined in the primary tumour and in the axilla. RESULTS: Eight tumours were visualized by (18)F-FLT-PET with a mean uptake value (SUV(mean)) of 1.7 and mean tumour-non-tumour ratio (TNT) of 5.0. In seven patients, axillary lymph-node metastases were found at pathological examinations, however, (18)F-FLT-PET showed uptake in only two large (and clinically evident) lymph-node metastases. CONCLUSIONS: (18)F-FLT shows uptake in most primary breast tumours and in large axillary lymph-node metastases.
BACKGROUND: This pilot study investigated the feasibility of (18)F-3'-deoxy-3'-fluoro-l-thymidine ((18)F-FLT) as a positron emission tomography (PET) tracer for the visualisation of breast cancer. METHODS:Patients with breast cancer underwent (18)F-FLT-PET prior to surgery. The uptake of (18)F-FLT was determined in the primary tumour and in the axilla. RESULTS: Eight tumours were visualized by (18)F-FLT-PET with a mean uptake value (SUV(mean)) of 1.7 and mean tumour-non-tumour ratio (TNT) of 5.0. In seven patients, axillary lymph-node metastases were found at pathological examinations, however, (18)F-FLT-PET showed uptake in only two large (and clinically evident) lymph-node metastases. CONCLUSIONS: (18)F-FLT shows uptake in most primary breast tumours and in large axillary lymph-node metastases.
Authors: K Pinker; P Brader; G Karanikas; K El-Rabadi; W Bogner; S Gruber; M Reisegger; S Trattnig; T H Helbich Journal: Radiologe Date: 2010-11 Impact factor: 0.635
Authors: Charles M Laymon; Matthew J Oborski; Vincent K Lee; Denise K Davis; Erik C Wiener; Frank S Lieberman; Fernando E Boada; James M Mountz Journal: Magn Reson Imaging Date: 2012-07-21 Impact factor: 2.546
Authors: David Viertl; Angelika Bischof Delaloye; Bernard Lanz; Carole Poitry-Yamate; Rolf Gruetter; Vladimir Mlynarik; Simon M Ametamey; Tobias L Ross; Hans-Anton Lehr; Pierre-Alain André; Florence Perillo-Adamer; Marek Kosinski; Yves M Dupertuis; Franz Buchegger Journal: Mol Imaging Biol Date: 2011-04 Impact factor: 3.488
Authors: Adrianus J de Langen; Bianca Klabbers; Mark Lubberink; Ronald Boellaard; Marieke D Spreeuwenberg; Ben J Slotman; Remco de Bree; Egbert F Smit; Otto S Hoekstra; Adriaan A Lammertsma Journal: Eur J Nucl Med Mol Imaging Date: 2008-10-18 Impact factor: 9.236
Authors: Iván Peñuelas; Inés Domínguez-Prado; María J García-Velloso; Josep M Martí-Climent; Macarena Rodríguez-Fraile; Carlos Caicedo; María Sánchez-Martínez; José A Richter Journal: J Oncol Date: 2012-08-29 Impact factor: 4.375