OBJECTIVE: To assess the role of hybrid PET/CT in the evaluation of patients with cervical cancer. METHODS: 75 patients divided into 3 groups. Group 1 consisted of 16 patients prior to radical surgery. Group 2 consisted of 31 patients prior to pelvic radiotherapy. Group 3 had 28 patients who underwent the examination secondary to suspected recurrent disease. Whole body PET and CT were performed respectively on the same device 1 h after injection of 10 mCi FDG. PET/CT results were correlated to histological, radiological and clinical follow-up data. Only women with >6 months follow-up were included. RESULTS: In 33 patients, pathohistological examinations for extra cervical lesions were obtained. Correlation with PET/CT examination revealed levels of sensitivity (60%), specificity (94%), positive (90%) and negative predictive values (74%). The examination indicated 21 patients with extrapelvic and/or metastatic disease. The follow-up data of this group revealed that 20 patients either died or were alive with active disease, and only one patient was in clinical remission. PET/CT yielded an improved diagnosis for both PET and CT in 43% of the cases by providing better localization and definition of abnormal FDG uptake. CONCLUSIONS: Hybrid PET/CT was found to be of value for detection of cervical cancer metastases, decision-making and planning of irradiation therapy. Using this modality may reduce unnecessary surgical interventions, help modify radiation fields and change therapeutic approaches. Detection of advanced diseases on PET/CT correlates with poor prognosis. However, this examination is less accurate in detecting microscopic diseases and lesions smaller than 1.5 cm.
OBJECTIVE: To assess the role of hybrid PET/CT in the evaluation of patients with cervical cancer. METHODS: 75 patients divided into 3 groups. Group 1 consisted of 16 patients prior to radical surgery. Group 2 consisted of 31 patients prior to pelvic radiotherapy. Group 3 had 28 patients who underwent the examination secondary to suspected recurrent disease. Whole body PET and CT were performed respectively on the same device 1 h after injection of 10 mCi FDG. PET/CT results were correlated to histological, radiological and clinical follow-up data. Only women with >6 months follow-up were included. RESULTS: In 33 patients, pathohistological examinations for extra cervical lesions were obtained. Correlation with PET/CT examination revealed levels of sensitivity (60%), specificity (94%), positive (90%) and negative predictive values (74%). The examination indicated 21 patients with extrapelvic and/or metastatic disease. The follow-up data of this group revealed that 20 patients either died or were alive with active disease, and only one patient was in clinical remission. PET/CT yielded an improved diagnosis for both PET and CT in 43% of the cases by providing better localization and definition of abnormal FDG uptake. CONCLUSIONS: Hybrid PET/CT was found to be of value for detection of cervical cancer metastases, decision-making and planning of irradiation therapy. Using this modality may reduce unnecessary surgical interventions, help modify radiation fields and change therapeutic approaches. Detection of advanced diseases on PET/CT correlates with poor prognosis. However, this examination is less accurate in detecting microscopic diseases and lesions smaller than 1.5 cm.
Authors: Perry W Grigsby; Robert S Malyapa; Ryuji Higashikubo; Julie K Schwarz; Michael J Welch; Phyllis C Huettner; Farrokh Dehdashti Journal: Mol Imaging Biol Date: 2007 Sep-Oct Impact factor: 3.488
Authors: Meng Xu-Welliver; William T C Yuh; Julia R Fielding; Katarzyna J Macura; Zhibin Huang; Ahmet S Ayan; Floor J Backes; Guang Jia; Mariam Moshiri; Jun Zhang; Nina A Mayr Journal: Radiographics Date: 2014 Jul-Aug Impact factor: 5.333
Authors: Erik Mittra; Tarek El-Maghraby; Cesar A Rodriguez; Andrew Quon; I Ross McDougall; Sanjiv S Gambhir; Andrei Iagaru Journal: Eur J Nucl Med Mol Imaging Date: 2009-12 Impact factor: 9.236
Authors: Astrid A M van der Veldt; Lotty Hooft; Paul J van Diest; Johannes Berkhof; Marrije R Buist; Emile F I Comans; Otto S Hoekstra; Carla F M Molthoff Journal: Eur J Nucl Med Mol Imaging Date: 2006-07-14 Impact factor: 10.057