OBJECTIVES: To evaluate the potential role of oxidative stress in the evolution of cervical cancer, including its pre-malignant states. DESIGN AND METHODS: Erythrocytes thiobarbituric acid reactive substances (TBARS) levels, plasma vitamin C and thiol content and total blood delta-ALA-D levels were estimated in 46 untreated cervical cancer and pre-malignant patients and in 46 age-sex-matched controls. RESULTS: Erythrocytes from patients, regardless of disease state, pre-malignant (low squamous intraepithelial lesion--LSIL and high squamous intraepithelial lesion--HSIL) or cancer, showed a significant 2-3 times increase in TBARS levels (P<0.01). Plasma vitamin C was lower in the carcinoma group (P<0.01). The reactivation index of delta-aminolevulinate dehydratase (delta-ALA-D) was higher in the patient group, when compared to control (P<0.01). CONCLUSION: LSIL, HSIL or cervical cancer can be associated with changes in 3 indicators of oxidative stress: increase in erythrocyte TBARS, ALA-D reactivation index and a decrease in vitamin C content, that may play an important role in carcinogenesis.
OBJECTIVES: To evaluate the potential role of oxidative stress in the evolution of cervical cancer, including its pre-malignant states. DESIGN AND METHODS: Erythrocytes thiobarbituric acid reactive substances (TBARS) levels, plasma vitamin C and thiol content and total blood delta-ALA-D levels were estimated in 46 untreated cervical cancer and pre-malignant patients and in 46 age-sex-matched controls. RESULTS: Erythrocytes from patients, regardless of disease state, pre-malignant (low squamous intraepithelial lesion--LSIL and high squamous intraepithelial lesion--HSIL) or cancer, showed a significant 2-3 times increase in TBARS levels (P<0.01). Plasma vitamin C was lower in the carcinoma group (P<0.01). The reactivation index of delta-aminolevulinate dehydratase (delta-ALA-D) was higher in the patient group, when compared to control (P<0.01). CONCLUSION: LSIL, HSIL or cervical cancer can be associated with changes in 3 indicators of oxidative stress: increase in erythrocyte TBARS, ALA-D reactivation index and a decrease in vitamin C content, that may play an important role in carcinogenesis.
Authors: Enrique F Schisterman; Audrey J Gaskins; Sunni L Mumford; Richard W Browne; Edwina Yeung; Maurizio Trevisan; Mary Hediger; Cuilin Zhang; Neil J Perkins; Kathleen Hovey; Jean Wactawski-Wende Journal: Am J Epidemiol Date: 2010-08-01 Impact factor: 4.897
Authors: Thissiane L Gonçalves; Dalila M Benvegnú; Gabriela Bonfanti; Andressa V Frediani; João Batista T Rocha Journal: BMC Cancer Date: 2009-05-08 Impact factor: 4.430