Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Mild and reversible dehydration of primary amides with PdCl2 in aqueous acetonitrile.

Literature DB >> 16268547

Mild and reversible dehydration of primary amides with PdCl2 in aqueous acetonitrile.

Sonia I Maffioli¹, Ettore Marzorati, Alessandra Marazzi.

Abstract

[reaction: see text] A new, mild, and reversible method to convert primary amides to nitriles in good yields using PdCl2 in aqueous acetonitrile is described.

Entities: Chemical Disease

Year: 2005 PMID： 16268547 DOI： 10.1021/ol052100l

Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005

Keyword Cloud
Cited

9 in total

1. Synthesis and evaluation of oryzalin analogs against Toxoplasma gondii.

Authors: Molla M Endeshaw; Catherine Li; Jessica de Leon; Ni Yao; Kirk Latibeaudiere; Kokku Premalatha; Naomi Morrissette; Karl A Werbovetz
Journal: Bioorg Med Chem Lett Date: 2010-07-08 Impact factor: 2.823

2. Synthesis of nitriles via palladium-catalyzed water shuffling from amides to acetonitrile.

Authors: Wandi Zhang; Christopher W Haskins; Yang Yang; Mingji Dai
Journal: Org Biomol Chem Date: 2014-12-07 Impact factor: 3.876

3. Antibacterial Nucleoside-Analog Inhibitor of Bacterial RNA Polymerase.

Authors: Sonia I Maffioli; Yu Zhang; David Degen; Thomas Carzaniga; Giancarlo Del Gatto; Stefania Serina; Paolo Monciardini; Carlo Mazzetti; Paola Guglierame; Gianpaolo Candiani; Alina Iulia Chiriac; Giuseppe Facchetti; Petra Kaltofen; Hans-Georg Sahl; Gianni Dehò; Stefano Donadio; Richard H Ebright
Journal: Cell Date: 2017-06-15 Impact factor: 41.582

4. Mechanistic Insight Facilitates Discovery of a Mild and Efficient Copper-Catalyzed Dehydration of Primary Amides to Nitriles Using Hydrosilanes.

Authors: Richard Y Liu; Minwoo Bae; Stephen L Buchwald
Journal: J Am Chem Soc Date: 2018-01-29 Impact factor: 15.419

5. Synthesis, biological evaluation, and molecular modeling of 3,5-substituted-N1-phenyl-N4,N4-di-n-butylsulfanilamides as antikinetoplastid antimicrotubule agents.

Authors: Tesmol G George; Molla M Endeshaw; Rachel E Morgan; Kiran V Mahasenan; Dawn A Delfín; Mitali S Mukherjee; Adam J Yakovich; Jean Fotie; Chenglong Li; Karl A Werbovetz
Journal: Bioorg Med Chem Date: 2007-06-27 Impact factor: 3.641

Mild and reversible dehydration of primary amides with PdCl2 in aqueous acetonitrile.

1. Synthesis and evaluation of oryzalin analogs against Toxoplasma gondii.

2. Synthesis of nitriles via palladium-catalyzed water shuffling from amides to acetonitrile.

3. Antibacterial Nucleoside-Analog Inhibitor of Bacterial RNA Polymerase.

4. Mechanistic Insight Facilitates Discovery of a Mild and Efficient Copper-Catalyzed Dehydration of Primary Amides to Nitriles Using Hydrosilanes.

5. Synthesis, biological evaluation, and molecular modeling of 3,5-substituted-N1-phenyl-N4,N4-di-n-butylsulfanilamides as antikinetoplastid antimicrotubule agents.

6. Oxidative 1,2-carboamination of alkenes with alkyl nitriles and amines toward γ-amino alkyl nitriles.

7. Efficient iron single-atom catalysts for selective ammoxidation of alcohols to nitriles.

8. Direct Oxidation of Aryl Malononitriles Enabling a Copper-Catalyzed Intermolecular Alkene Carbochlorination.

9. Development and Utilization of a Palladium-Catalyzed Dehydration of Primary Amides To Form Nitriles.