Literature DB >> 16267577

Probing dipeptide trans/cis stereochemistry using pH control of thiopeptide analogues, and application to the PepT1 transporter.

Patrick D Bailey1, C A Richard Boyd, Ian D Collier, George L Kellett, David Meredith, Keith M Morgan, Rachel Pettecrew, Richard A Price.   

Abstract

The stereochemistry of thiodipeptides of proline [e.g. Ala-Psi[CS-N]-Pro] can be controlled using pH, allowing the trans-preference for substrates of the peptide transporter PepT1 to be confirmed.

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Year:  2005        PMID： 16267577     DOI： 10.1039/b513274f

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN： 1477-0520            Impact factor:   3.876


  4 in total

Review 1.  Bioavailability through PepT1: the role of computer modelling in intelligent drug design.

Authors:  David W Foley; Jeyaganesh Rajamanickam; Patrick D Bailey; David Meredith
Journal:  Curr Comput Aided Drug Des       Date:  2010-03       Impact factor: 1.606

2.  An energy supply network of nutrient absorption coordinated by calcium and T1R taste receptors in rat small intestine.

Authors:  Oliver J Mace; Norma Lister; Emma Morgan; Emma Shepherd; Julie Affleck; Philip Helliwell; John R Bronk; George L Kellett; David Meredith; Richard Boyd; Myrtani Pieri; Pat D Bailey; Rachel Pettcrew; David Foley
Journal:  J Physiol       Date:  2008-11-10       Impact factor: 5.182

3.  Partial thioamide scan on the lipopeptaibiotic trichogin GA IV. Effects on folding and bioactivity.

Authors:  Marta De Zotti; Barbara Biondi; Cristina Peggion; Matteo De Poli; Haleh Fathi; Simona Oancea; Claudio Toniolo; Fernando Formaggio
Journal:  Beilstein J Org Chem       Date:  2012-07-24       Impact factor: 2.883

4.  Thiodipeptides targeting the intestinal oligopeptide transporter as a general approach to improving oral drug delivery.

Authors:  David W Foley; Ravindra B Pathak; Theresa R Phillips; Gayle L Wilson; Patrick D Bailey; Myrtani Pieri; Anish Senan; David Meredith
Journal:  Eur J Med Chem       Date:  2018-06-30       Impact factor: 6.514
  4 in total

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