AIMS: To evaluate cardiac response to exercise in middle-aged normotensive obstructive sleep apnoea-hypoapnoea syndrome (OSAHS) adults with normal resting left ventricular systolic function and to test the hypothesis that nasal continuous positive airway pressure (CPAP) therapy might improve cardiac performance during exercise. METHODS AND RESULTS: We performed a prospective, randomized, double-blind, placebo-controlled, cross-over clinical trial including 31 consecutive newly diagnosed OSAHS patients and 15 healthy subjects. Cardiopulmonary exercise testing with cardiac output measurement, blood pressure (BP) recordings, and urinary excretion of catecholamine levels were obtained at baseline and after 3 months on both effective and sham CPAP. OSAHS subjects had higher systolic and mean nocturnal BP and higher nocturnal levels of catecholamines. In contrast, they had lower increments in cardiac output (Qt) and in stroke volume (SV) in response to exercise than control subjects. CPAP therapy was associated with highly significant improvements in all the indices of left ventricular systolic performance response during exercise, whereas with sham CPAP, all of them remained unchanged. CONCLUSION:OSAHS patients with normal resting left ventricular systolic function and no hypertension had a worse cardiac response to exercise than healthy subjects. In these patients, 3 months of CPAP improved both Qt and SV responses to exercise.
RCT Entities:
AIMS: To evaluate cardiac response to exercise in middle-aged normotensive obstructive sleep apnoea-hypoapnoea syndrome (OSAHS) adults with normal resting left ventricular systolic function and to test the hypothesis that nasal continuous positive airway pressure (CPAP) therapy might improve cardiac performance during exercise. METHODS AND RESULTS: We performed a prospective, randomized, double-blind, placebo-controlled, cross-over clinical trial including 31 consecutive newly diagnosed OSAHSpatients and 15 healthy subjects. Cardiopulmonary exercise testing with cardiac output measurement, blood pressure (BP) recordings, and urinary excretion of catecholamine levels were obtained at baseline and after 3 months on both effective and sham CPAP. OSAHS subjects had higher systolic and mean nocturnal BP and higher nocturnal levels of catecholamines. In contrast, they had lower increments in cardiac output (Qt) and in stroke volume (SV) in response to exercise than control subjects. CPAP therapy was associated with highly significant improvements in all the indices of left ventricular systolic performance response during exercise, whereas with sham CPAP, all of them remained unchanged. CONCLUSION:OSAHSpatients with normal resting left ventricular systolic function and no hypertension had a worse cardiac response to exercise than healthy subjects. In these patients, 3 months of CPAP improved both Qt and SV responses to exercise.
Authors: Hannah V Fletcher; Peter S P Cho; Stewart Lee Loong; Luis Estrada-Petrocelli; Amit S Patel; Surinder S Birring; Kai K Lee Journal: J Clin Sleep Med Date: 2020-11-15 Impact factor: 4.062
Authors: Michele Vitacca; Mara Paneroni; Alberto Braghiroli; Bruno Balbi; Maria Aliani; Patrizia Guido; Francesco Fanfulla; Mario Pertosa; Piero Ceriana; Elisabetta Zampogna; Rita Raccanelli; Nicola Sarno; Antonio Spanevello; Mauro Maniscalco; Alberto Malovini; Nicolino Ambrosino Journal: J Clin Sleep Med Date: 2020-04-15 Impact factor: 4.062
Authors: Bruno Teixeira Barbosa; Amilton da Cruz Santos; Murillo Frazão; Tulio Rocha Petrucci; Gabriel Grizzo Cucato; Adriana Oliveira Sarmento; Eduardo D S Freitas; Anna Myrna Jaguaribe de Lima; Maria do Socorro Brasileiro-Santos Journal: Sleep Breath Date: 2017-08-24 Impact factor: 2.816