Literature DB >> 16266128

Structure elucidation of Sch 725674 from Aspergillus sp.

Shu-Wei Yang1, Tze-Ming Chan, Joseph Terracciano, David Loebenberg, Mahesh Patel, Min Chu.   

Abstract

A new macrolide Sch725674 (1) was isolated and identified from the culture of an Aspergillus sp. The structure elucidation of 1 was accomplished based on extensive NMR spectroscopic analyses. Compound 1 showed inhibitory activity against Saccharomyces cerevisiae (PM503) and Candida albicans (C43) with MICs of 8 and 32 microg/ml, respectively.

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Year:  2005        PMID： 16266128     DOI： 10.1038/ja.2005.74

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  5 in total

1.  Modular Synthesis of Novel Macrocycles Bearing α,β-Unsaturated Chemotypes through a Series of One-Pot, Sequential Protocols.

Authors:  Salim Javed; Mahipal Bodugam; Jessica Torres; Arghya Ganguly; Paul R Hanson
Journal:  Chemistry       Date:  2016-04-05       Impact factor: 5.236

2.  Minimal fluorous tagging strategy that enables the synthesis of the complete stereoisomer library of SCH725674 macrolactones.

Authors:  Jared D Moretti; Xiao Wang; Dennis P Curran
Journal:  J Am Chem Soc       Date:  2012-05-01       Impact factor: 15.419

3.  Comparison of the Relative Reactivities of the Triisopropylsilyl Group With Two Fluorous Analogs.

Authors:  Amador Garcia Sancho; Xiao Wang; Bin Sui; Dennis Curran
Journal:  Adv Synth Catal       Date:  2009-05-01       Impact factor: 5.837

4.  A Pot-Economical Approach to the Total Synthesis of Sch-725674.

Authors:  Mahipal Bodugam; Salim Javed; Arghya Ganguly; Jessica Torres; Paul R Hanson
Journal:  Org Lett       Date:  2016-01-13       Impact factor: 6.005

5.  Regio- and Stereoselective Homologation of 1,2-Bis(Boronic Esters): Stereocontrolled Synthesis of 1,3-Diols and Sch 725674.

Authors:  Alexander Fawcett; Dominik Nitsch; Muhammad Ali; Joseph M Bateman; Eddie L Myers; Varinder K Aggarwal
Journal:  Angew Chem Int Ed Engl       Date:  2016-10-26       Impact factor: 15.336
  5 in total

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