Literature DB >> 16263578

Immune recovery after conventional and non-myeloablative allogeneic stem cell transplantation.

Axel Schulenburg1, Michael Fischer, Peter Kalhs, Margit Mitterbauer, Werner Rabitsch, Hildegard T Greinix, Gerda Leitner.   

Abstract

The immune recovery of 66 patients undergoing allogeneic stem cell transplantation with either conventional or non-myeloablative conditioning regimen was studied. Infections post-transplant were enumerated and quantitative immunoglobuilins (IgG, IgA, IgM) and lymphocyte sub-sets 3, 6 and 12 months post-transplant were measured. A significant difference was found in the immunologic recovery of non-myeloablative and conventional ASCT in the patient population. The T-helper cell reconstitution was significantly faster after NMA than conventional transplantation and the recovery of B cells was faster after conventional transplantation. Regarding immunoglobulin levels, a faster recovery of IgM levels after NMA-ASCT and a delayed recovery of IgA levels was observed in both groups. These were accompanied by a significant difference in the frequency and severity of infectious episodes.

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Mesh：

Year:  2005        PMID： 16263578     DOI： 10.1080/10428190500264496

Source DB:  PubMed          Journal:  Leuk Lymphoma        ISSN： 1026-8022


  6 in total

1.  High incidence of herpes zoster in nonmyeloablative hematopoietic stem cell transplantation.

Authors:  Shih Hann Su; Valérie Martel-Laferrière; Annie-Claude Labbé; David R Snydman; David Kent; Michel Laverdière; Claire Béliveau; Tanya Logvinenko; Sandra Cohen; Silvy Lachance; Thomas Kiss; Jean Roy
Journal:  Biol Blood Marrow Transplant       Date:  2010-10-25       Impact factor: 5.742

2.  A comparison of immune reconstitution and graft-versus-host disease following myeloablative conditioning versus reduced toxicity conditioning and umbilical cord blood transplantation in paediatric recipients.

Authors:  Mark B Geyer; Judith S Jacobson; Jason Freedman; Diane George; Virginia Moore; Carmella van de Ven; Prakash Satwani; Monica Bhatia; James H Garvin; Mary Brigid Bradley; Lauren Harrison; Erin Morris; Phyllis Della-Latta; Joseph Schwartz; Lee A Baxter-Lowe; Mitchell S Cairo
Journal:  Br J Haematol       Date:  2011-08-16       Impact factor: 6.998

3.  Immune reconstitution and cytomegalovirus infection after allogeneic stem cell transplantation: the important impact of in vivo T cell depletion.

Authors:  Martin Schmidt-Hieber; S Schwarck; A Stroux; S Ganepola; P Reinke; E Thiel; L Uharek; I W Blau
Journal:  Int J Hematol       Date:  2010-05-21       Impact factor: 2.490

Review 4.  National Institutes of Health Hematopoietic Cell Transplantation Late Effects Initiative: The Immune Dysregulation and Pathobiology Working Group Report.

Authors:  Juan Gea-Banacloche; Krishna V Komanduri; Paul Carpenter; Sophie Paczesny; Stefanie Sarantopoulos; Jo-Anne Young; Nahed El Kassar; Robert Q Le; Kirk R Schultz; Linda M Griffith; Bipin N Savani; John R Wingard
Journal:  Biol Blood Marrow Transplant       Date:  2016-10-14       Impact factor: 5.742

5.  Immune Reconstitution Kinetics following Intentionally Induced Mixed Chimerism by Nonmyeloablative Transplantation.

Authors:  Nayoun Kim; Hyunji Lee; Junghoon Shin; Young-Sun Nam; Keon-Il Im; Jung-Yeon Lim; Eun-Sol Lee; Young-Nam Kang; Se-Ho Park; Seok-Goo Cho
Journal:  PLoS One       Date:  2015-05-11       Impact factor: 3.240

6.  Joint Modeling of Immune Reconstitution Post Haploidentical Stem Cell Transplantation in Pediatric Patients With Acute Leukemia Comparing CD34+-Selected to CD3/CD19-Depleted Grafts in a Retrospective Multicenter Study.

Authors:  Emilia Salzmann-Manrique; Melanie Bremm; Sabine Huenecke; Milena Stech; Andreas Orth; Matthias Eyrich; Ansgar Schulz; Ruth Esser; Thomas Klingebiel; Peter Bader; Eva Herrmann; Ulrike Koehl
Journal:  Front Immunol       Date:  2018-08-14       Impact factor: 7.561
  6 in total

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