| Literature DB >> 16263095 |
Andreas Meier1, Brit Mollenhauer, Stefan Cohrs, Andrea Rodenbeck, Wolfgang Jordan, Johannes Meller, Markus Otto.
Abstract
A significant atrophy and loss of hypocretin neurons in the brains of human patients with Huntington's disease (HD) and in R6/2 mice have been reported. We included 10 patients with HD and 12 patients with chorea-like hyperkinetic movement disorders (non-HD). All patients of the HD group and eleven patients of the non-HD group showed normal hypocretin-1 levels. Thus, hypocretin-1 may not serve as an additional diagnostic marker for HD.Entities:
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Year: 2005 PMID： 16263095 DOI： 10.1016/j.brainres.2005.09.028
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252