STUDY DESIGN: A subgroup analysis of patient outcomes from a double-blind randomized controlled study comparing corticosteroid versus saline in microscopic lumbar disc surgery. OBJECTIVES: To study if the use of corticosteroids combined with surgery alleviates the damage to the nerve fibers in lumbar disc herniation. SUMMARY OF BACKGROUND DATA: The use of quantitative sensory testing can detect damage to the myelinated A-delta fibers (cold sense) and the unmyelinated C-fibers (warmth sense). Corticosteroids combined with surgery in lumbar disc surgery enhance the outcome after surgery in terms of less pain and more rapid rehabilitation. METHODS: Analyzing quantitative sensory testing before surgery and after 2 weeks and 2 years. RESULTS: In the corticosteroid group, we saw a statistically significant normalization for the warmth disturbance comparing with control group, which not was detected concerning the cold disturbance. CONCLUSIONS: The use of corticosteroids combined with surgery seems to protect some of the damage to the C-fibers in lumbar disc herniation.
RCT Entities:
STUDY DESIGN: A subgroup analysis of patient outcomes from a double-blind randomized controlled study comparing corticosteroid versus saline in microscopic lumbar disc surgery. OBJECTIVES: To study if the use of corticosteroids combined with surgery alleviates the damage to the nerve fibers in lumbar disc herniation. SUMMARY OF BACKGROUND DATA: The use of quantitative sensory testing can detect damage to the myelinated A-delta fibers (cold sense) and the unmyelinated C-fibers (warmth sense). Corticosteroids combined with surgery in lumbar disc surgery enhance the outcome after surgery in terms of less pain and more rapid rehabilitation. METHODS: Analyzing quantitative sensory testing before surgery and after 2 weeks and 2 years. RESULTS: In the corticosteroid group, we saw a statistically significant normalization for the warmth disturbance comparing with control group, which not was detected concerning the cold disturbance. CONCLUSIONS: The use of corticosteroids combined with surgery seems to protect some of the damage to the C-fibers in lumbar disc herniation.
Authors: Matthew J McGirt; Kaisorn L Chaichana; April Atiba; Frank Attenello; Graeme F Woodworth; George I Jallo Journal: Childs Nerv Syst Date: 2007-07-31 Impact factor: 1.475
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Authors: Massimiliano Carassiti; Giuseppe Pascarella; Alessandro Strumia; Fabrizio Russo; Giuseppe Francesco Papalia; Rita Cataldo; Francesca Gargano; Fabio Costa; Michelangelo Pierri; Francesca De Tommasi; Carlo Massaroni; Emiliano Schena; Felice Eugenio Agrò Journal: Int J Environ Res Public Health Date: 2021-12-26 Impact factor: 3.390
Authors: Kourosh Zarghooni; Ali Rashidi; Jan Siewe; Marc Röllinghoff; Jan Bredow; Peer Eysel; Max J Scheyerer Journal: Orthop Rev (Pavia) Date: 2015-12-28