Literature DB >> 16260914

Performance of a T-cell-based diagnostic test for tuberculosis infection in HIV-infected individuals is independent of CD4 cell count.

Keertan Dheda1, Ajit Lalvani, Robert F Miller, Geoff Scott, Helen Booth, Margaret A Johnson, Alimuddin Zumla, Graham Aw Rook.   

Abstract

The performance characteristics of the enzyme-linked immunospot assay (ELISPOT) assay (T-SPOT TB) for the diagnosis of latent tuberculosis infection in HIV-infected individuals are unknown. Given that ELISPOT enumerates Mycobacterium tuberculosis antigen-specific IFN-gamma-secreting T cells, HIV-associated immunosuppression might adversely affect test performance. However, we found that 28 out of 29 HIV-positive individuals (97%) gave evaluable test results, and performance was independent of the CD4 T-cell count. ELISPOT test performance appears to be independent of HIV-associated immunosuppression.

Entities:  

Mesh：

Substances：

Year:  2005        PMID： 16260914     DOI： 10.1097/01.aids.0000191923.08938.5b

Source DB:  PubMed          Journal:  AIDS        ISSN： 0269-9370            Impact factor:   4.177


  33 in total

1.  Negative effect of immunosuppressive therapy in the performance of the QuantiFERON gold in-tube test in patients with immune-mediated inflammatory diseases.

Authors:  José M Ramos; Mar Masiá; Juan C Rodríguez; Cristina López; Sergio Padilla; Catalina Robledano; Francisco J Navarro-Blasco; Jaime Matarredona; Mariana F García-Sepulcre; Félix Gutiérrez
Journal:  Clin Exp Med       Date:  2012-06-27       Impact factor: 3.984

2.  Tuberculosis antigen-specific immune responses can be detected using enzyme-linked immunospot technology in human immunodeficiency virus (HIV)-1 patients with advanced disease.

Authors:  S A Clark; S L Martin; A Pozniak; A Steel; B Ward; J Dunning; D C Henderson; M Nelson; B Gazzard; P Kelleher
Journal:  Clin Exp Immunol       Date:  2007-08-02       Impact factor: 4.330

3.  Progressive symptoms and signs following institution of highly active antiretroviral therapy and subsequent antituberculosis therapy: immune reconstitution syndrome or infection?

Authors:  R F Miller; M Shahmanesh; M D Talbot; M J Wiselka; P J Shaw; C Bacon; C M Robertson
Journal:  Sex Transm Infect       Date:  2006-04       Impact factor: 3.519

4.  Follow-up study of tuberculosis-exposed supermarket customers with negative tuberculin skin test results in association with positive gamma interferon release assay results.

Authors:  Willeke P J Franken; Ben F P J Koster; Ailko W J Bossink; Steven F T Thijsen; John J M Bouwman; Jaap T van Dissel; Sandra M Arend
Journal:  Clin Vaccine Immunol       Date:  2007-07-11

5.  Performance of two commercial blood IFN-gamma release assays for the detection of Mycobacterium tuberculosis infection in patient candidates for anti-TNF-alpha treatment.

Authors:  M Bocchino; A Matarese; B Bellofiore; P Giacomelli; G Santoro; N Balato; F Castiglione; R Scarpa; F Perna; G Signoriello; D Galati; A Ponticiello; A Sanduzzi
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2008-05-10       Impact factor: 3.267

6.  Analysis of predictors influencing indeterminate whole-blood interferon-gamma release assay results in patients with rheumatic diseases.

Authors:  Hyun-Ju Jung; Tae-Jong Kim; Hyoung-Sang Kim; Young-Nan Cho; Hye-Mi Jin; Moon-Ju Kim; Jeong-Hwa Kang; Ki-Jeong Park; Sung-Ji Lee; Shin-Seok Lee; Yong-Soo Kwon; Dae-Hyun Yoo; Seung-Jung Kee; Yong-Wook Park
Journal:  Rheumatol Int       Date:  2014-05-12       Impact factor: 2.631

7.  Interpreting tuberculin skin tests in a population with a high prevalence of HIV, tuberculosis, and nonspecific tuberculin sensitivity.

Authors:  Peter J Dodd; Kerry A Millington; Azra C Ghani; Junior Mutsvangwa; Anthony E Butterworth; Ajit Lalvani; Elizabeth L Corbett
Journal:  Am J Epidemiol       Date:  2010-04-09       Impact factor: 4.897

8.  Different screening strategies (single or dual) for the diagnosis of suspected latent tuberculosis: a cost effectiveness analysis.

Authors:  Anil Pooran; Helen Booth; Robert F Miller; Geoff Scott; Motasim Badri; Jim F Huggett; Graham Rook; Alimuddin Zumla; Keertan Dheda
Journal:  BMC Pulm Med       Date:  2010-02-22       Impact factor: 3.317

Review 9.  New diagnostic methods for tuberculosis.

Authors:  Melissa R Nyendak; Deborah A Lewinsohn; David M Lewinsohn
Journal:  Curr Opin Infect Dis       Date:  2009-04       Impact factor: 4.915

10.  High-sensitive and rapid detection of Mycobacterium tuberculosis infection by IFN-gamma release assay among HIV-infected individuals in BCG-vaccinated area.

Authors:  Weimin Jiang; Lingyun Shao; Ying Zhang; Shu Zhang; Chengyan Meng; Yunya Xu; Lingli Huang; Yun Wang; Ying Wang; Xinhua Weng; Wenhong Zhang
Journal:  BMC Immunol       Date:  2009-05-28       Impact factor: 3.615
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.