Literature DB >> 1626072

Antibodies to snRNPs in systemic lupus erythematosus.

J Craft1.   

Abstract

Antibodies to the Sm and RNP antigens are diagnostic hallmarks in patients with systemic lupus erythematosus. Both antigens are located on the U1 snRNP (small nuclear ribonucleoprotein particle), a complex of a small RNA and associated proteins that carry the antigenic determinants. This particle also plays an essential role in messenger RNA processing within the cell nucleus. Newer diagnostic techniques are available for detection of anti-Sm and antiRNP antibodies (the latter are now more appropriately called anti-U1 RNP antibodies) and a great deal of information on the molecular biology of snRNPs is currently available.

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Year:  1992        PMID： 1626072

Source DB:  PubMed          Journal:  Rheum Dis Clin North Am        ISSN： 0889-857X            Impact factor:   2.670


  18 in total

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3.  A U2-snRNP-independent role of SF3b in promoting mRNA export.

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4.  Prolidase deficiency breaks tolerance to lupus-associated antigens.

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7.  Clinical and serological features of patients with autoantibodies to GW/P bodies.

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8.  Distinctive immune response patterns of human and murine autoimmune sera to U1 small nuclear ribonucleoprotein C protein.

Authors:  M Satoh; J J Langdon; K J Hamilton; H B Richards; D Panka; R A Eisenberg; W H Reeves
Journal:  J Clin Invest       Date:  1996-06-01       Impact factor: 14.808

Review 9.  Laboratory evaluation of the inflammatory myopathies.

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10.  Type I interferon receptor controls B-cell expression of nucleic acid-sensing Toll-like receptors and autoantibody production in a murine model of lupus.

Authors:  Donna L Thibault; Kareem L Graham; Lowen Y Lee; Imelda Balboni; Paul J Hertzog; Paul J Utz
Journal:  Arthritis Res Ther       Date:  2009-07-22       Impact factor: 5.156
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