Literature DB >> 16260083

KAI1/CD82, a tumor metastasis suppressor.

Wei M Liu1, Xin A Zhang.   

Abstract

Tetraspanin KAI1/CD82 is a wide-spectrum tumor metastasis suppressor. KAI1/CD82 suppresses tumor metastasis by primarily inhibiting cancer cell motility and invasiveness. In tetraspanin-enriched microdomain, KAI1/CD82 associates with the proteins important for cell migration such as cell adhesion molecule, growth factor receptor, and signaling molecule. Likely, KAI1/CD82 down-regulates the functions of these motility-related proteins to inhibit cell migration. The loss of KAI1/CD82 expression in invasive and metastatic cancers is due to a complex, epigenetic mechanism that probably involves transcription factors such as NFkappaB, p53, and beta-catenin.

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Year:  2005        PMID： 16260083     DOI： 10.1016/j.canlet.2005.08.018

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  49 in total

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Review 3.  Metastasis suppressor proteins: discovery, molecular mechanisms, and clinical application.

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4.  CD82 endocytosis and cholesterol-dependent reorganization of tetraspanin webs and lipid rafts.

Authors:  Congfeng Xu; Yanhui H Zhang; Muthusamy Thangavel; Mekel M Richardson; Li Liu; Bin Zhou; Yi Zheng; Rennolds S Ostrom; Xin A Zhang
Journal:  FASEB J       Date:  2009-06-04       Impact factor: 5.191

Review 5.  Tetraspanins: push and pull in suppressing and promoting metastasis.

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Journal:  Nat Rev Cancer       Date:  2008-12-11       Impact factor: 60.716

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Authors:  Sharleen V Menezes; Sumit Sahni; Zaklina Kovacevic; Des R Richardson
Journal:  J Biol Chem       Date:  2017-06-14       Impact factor: 5.157

7.  CXCL12 controls over-invasion of trophoblasts via upregulating CD82 expression in DSCs at maternal-fetal interface of human early pregnancy in a paracrine manner.

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8.  Differential functions of phospholipid binding and palmitoylation of tumour suppressor EWI2/PGRL.

Authors:  Bo He; Yanhui H Zhang; Mekel M Richardson; Julian S Zhang; Eric Rubinstein; Xin A Zhang
Journal:  Biochem J       Date:  2011-08-01       Impact factor: 3.857

9.  ALY as a potential contributor to metastasis in human oral squamous cell carcinoma.

Authors:  Yasuhiro Saito; Atsushi Kasamatsu; Ayumi Yamamoto; Toshihiro Shimizu; Hidetaka Yokoe; Yosuke Sakamoto; Katsunori Ogawara; Masashi Shiiba; Hideki Tanzawa; Katsuhiro Uzawa
Journal:  J Cancer Res Clin Oncol       Date:  2012-12-15       Impact factor: 4.553

Review 10.  Contribution of p53 to metastasis.

Authors:  Emily Powell; David Piwnica-Worms; Helen Piwnica-Worms
Journal:  Cancer Discov       Date:  2014-03-21       Impact factor: 39.397
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