| Literature DB >> 16260053 |
Konstantinos P Letsas, Ioannis P Alexanian, Loukas K Pappas, Stavros P Kounas, Michalis Efremidis, Antonios Sideris, Fotis Kardaras.
Abstract
Direct blockade of the delayed rectifier repolarising potassium current is the major underlying mechanism of drug-induced QT interval prolongation. Indapamide is a well known blocker of the slow component of the delayed rectifier current leading to prolongation of cardiac repolarization. The case of an acquired long QT and torsade de pointes ventricular tachycardia in a woman with systemic lupus erythematosus and hypertension receiving prednisolone and indapamide, respectively, is described in the present report.Entities:
Mesh：
Substances：
Year: 2005 PMID： 16260053 DOI： 10.1016/j.ijcard.2005.07.055
Source DB: PubMed Journal: Int J Cardiol ISSN： 0167-5273 Impact factor: 4.164