OBJECTIVE: To assess the usefulness of the General Behavior Inventory (GBI) to predict the development of mood disorders in the offspring of parents with bipolar disorder. METHOD: The GBI and the K-SADS (first measurement) and the SCID (last measurement) were used to assess psychopathology among 129 adolescent and young adult offspring of a bipolar parent with an interval of 5 years. Based on the SCID results at the last measurement, the offspring were assigned to one of four groups: with bipolar mood disorder, with unipolar mood disorders, with non-mood disorders and without disorders and GBI-scores at the first measurement were compared across the four groups. RESULTS: The scores on the Depression scale of the GBI for the offspring who later developed a bipolar or any mood disorder were significantly higher than for the offspring who did not develop a mood disorder across a 5-year interval. For the offspring with a unipolar mood disorder at the first measurement, the scores on the Depression scale were significantly higher for those who switched to bipolar disorder versus those who remained unipolar. CONCLUSIONS: The GBI can be used in a high-risk sample of offspring of parents with bipolar disorder as a self-report measure as an aid to detect those who will develop bipolar disorder across a 5-year interval.
OBJECTIVE: To assess the usefulness of the General Behavior Inventory (GBI) to predict the development of mood disorders in the offspring of parents with bipolar disorder. METHOD: The GBI and the K-SADS (first measurement) and the SCID (last measurement) were used to assess psychopathology among 129 adolescent and young adult offspring of a bipolar parent with an interval of 5 years. Based on the SCID results at the last measurement, the offspring were assigned to one of four groups: with bipolar mood disorder, with unipolar mood disorders, with non-mood disorders and without disorders and GBI-scores at the first measurement were compared across the four groups. RESULTS: The scores on the Depression scale of the GBI for the offspring who later developed a bipolar or any mood disorder were significantly higher than for the offspring who did not develop a mood disorder across a 5-year interval. For the offspring with a unipolar mood disorder at the first measurement, the scores on the Depression scale were significantly higher for those who switched to bipolar disorder versus those who remained unipolar. CONCLUSIONS: The GBI can be used in a high-risk sample of offspring of parents with bipolar disorder as a self-report measure as an aid to detect those who will develop bipolar disorder across a 5-year interval.
Authors: Rasim Somer Diler; Boris Birmaher; David Axelson; Mihaela Obreja; Kelly Monk; Mary Beth Hickey; Benjamin Goldstein; Tina Goldstein; Dara Sakolsky; Satish Iyengar; David Brent; David Kupfer Journal: Bipolar Disord Date: 2011 Nov-Dec Impact factor: 6.744
Authors: Thomas W Frazier; Eric A Youngstrom; Sarah McCue Horwitz; Christine A Demeter; Mary A Fristad; L Eugene Arnold; Boris Birmaher; Robert A Kowatch; David Axelson; Neal Ryan; Mary Kay Gill; Robert L Findling Journal: J Clin Psychiatry Date: 2011-03-22 Impact factor: 4.384
Authors: Christoph U Correll; Doreen M Olvet; Andrea M Auther; Marta Hauser; Taishiro Kishimoto; Ricardo E Carrión; Stephanie Snyder; Barbara A Cornblatt Journal: Bipolar Disord Date: 2014-05-08 Impact factor: 6.744
Authors: Anna Van Meter; Eric Youngstrom; Andrew Freeman; Norah Feeny; Jennifer Kogos Youngstrom; Robert L Findling Journal: J Child Adolesc Psychopharmacol Date: 2016-02-02 Impact factor: 2.576