| Literature DB >> 16259959 |
Jingyu Zhang1, Xia Wang, Bing Chen, Guangli Suo, Yanhong Zhao, Ziyuan Duan, Jianwu Dai.
Abstract
Cells are the functional elements in tissue engineering and regenerative medicine. A large number of cells are usually needed for these purposes. However, there are numbers of limitations for in vitro cell proliferation. Nanog is an important self-renewal determinant in embryonic stem cells. However, it remains unknown whether Nanog will influence the cell cycle and cell proliferation of mature cells. In this study, we expressed Nanog in NIH3T3 cells and showed that expression of Nanog in NIH3T3 promoted cells to enter into S phase and enhanced cell proliferation. This suggests that Nanog gene might function in a similar fashion in mature cells as in ES cells. In addition, it may provide an approach for in vitro cell expansion.Entities:
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Year: 2005 PMID： 16259959 DOI： 10.1016/j.bbrc.2005.10.071
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575