Literature DB >> 16259723

The kallikrein-kinin system: from mediator of inflammation to modulator of cardioprotection.

Jagdish N Sharma1.   

Abstract

Kinin is an important mediator of hyperalgesia, inflammatory conditions and asthma. It causes pain, inflammation, increased vascular permeability and vasodilatation. Several kinin antagonists have been developed with the aim of treating these pathologies. Kinin B2 receptor agonists and kallikrein may have clinical utility in the treatment of hypertension, left ventricular hypertrophy, ischemic heart disease, congestive heart failure and diabetes. However, there is a need to know whether there is a safe therapeutic window between potential cardio-protective and pro-inflammatory effects following administration of kinin B2 receptor agonists.

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Year:  2005        PMID： 16259723     DOI： 10.1163/156856005774382760

Source DB:  PubMed          Journal:  Inflammopharmacology        ISSN： 0925-4692            Impact factor:   4.473


  19 in total

1.  Evaluation of tissue kallikrein activity on survival time after acute coronary artery ligation in hypertensive rats.

Authors:  Jagdish N Sharma; S Atif Abbas; A Pauzi M Yusof; Rajesh P Shah
Journal:  Int Immunopharmacol       Date:  2003-03       Impact factor: 4.932

2.  Bradykinin prevents left ventricular hypertrophy in rats.

Authors:  W Linz; G Wiemer; B A Schölkens
Journal:  J Hypertens Suppl       Date:  1993-12

3.  Studies on the mediators of the acute inflammatory response induced in rats in different sites by carrageenan and turpentine.

Authors:  M Di Rosa; J P Giroud; D A Willoughby
Journal:  J Pathol       Date:  1971-05       Impact factor: 7.996

4.  Altered urinary kallikrein excretion in rats with hypertension.

Authors:  H S Margolius; R Geller; W De Jong; J J Pisano; A Sjoerdsma
Journal:  Circ Res       Date:  1972-03       Impact factor: 17.367

5.  Inhibition of rats adjuvant arthritis by a bradykinin antagonist Hoe 140 and its influence on kallikreins.

Authors:  J N Sharma; K J Wirth
Journal:  Gen Pharmacol       Date:  1996-01

6.  A comparison of the effects of locally and systemically administered kinins on coronary blood flow and myocardial metabolism.

Authors:  W Lochner; J R Parratt
Journal:  Br J Pharmacol Chemother       Date:  1966-01

Review 7.  Cardiovascular properties of the kallikrein-kinin system.

Authors:  Jagdish N Sharma; Jyoti Sharma
Journal:  Curr Med Res Opin       Date:  2002       Impact factor: 2.580

Review 8.  Pathogenic responses of bradykinin system in chronic inflammatory rheumatoid disease.

Authors:  J N Sharma; W W Buchanan
Journal:  Exp Toxicol Pathol       Date:  1994-12

Review 9.  Does the kinin system mediate in cardiovascular abnormalities? An overview.

Authors:  Jagdish N Sharma
Journal:  J Clin Pharmacol       Date:  2003-11       Impact factor: 3.126

Review 10.  The role of kinin system in joint inflammatory disease.

Authors:  J N Sharma
Journal:  Eur J Rheumatol Inflamm       Date:  1991
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  9 in total

1.  Regulatory effects of ferritin on angiogenesis.

Authors:  Lan G Coffman; Derek Parsonage; Ralph D'Agostino; Frank M Torti; Suzy V Torti
Journal:  Proc Natl Acad Sci U S A       Date:  2009-01-06       Impact factor: 11.205

2.  Modifications in tissue kallikrein activity with indomethacin and prednisolone treatment in arthritic rats.

Authors:  J N Sharma
Journal:  Inflammopharmacology       Date:  2010-02-27       Impact factor: 4.473

Review 3.  The kinin system in hypertensive pathophysiology.

Authors:  Jagdish N Sharma
Journal:  Inflammopharmacology       Date:  2012-04-17       Impact factor: 4.473

Review 4.  Serum ferritin: Past, present and future.

Authors:  Wei Wang; Mary Ann Knovich; Lan G Coffman; Frank M Torti; Suzy V Torti
Journal:  Biochim Biophys Acta       Date:  2010-03-19

Review 5.  The Antifibrotic and the Anticarcinogenic Activity of Capsaicin in Hot Chili Pepper in Relation to Oral Submucous Fibrosis.

Authors:  Zoufang Huang; Mohit Sharma; Aparna Dave; Yuqi Yang; Zhe-Sheng Chen; Raghu Radhakrishnan
Journal:  Front Pharmacol       Date:  2022-05-04       Impact factor: 5.988

6.  The role of the kallikrein-kinin system genes in the salt sensitivity of blood pressure: the GenSalt Study.

Authors:  Dongfeng Gu; Qi Zhao; Tanika N Kelly; James E Hixson; Dabeeru C Rao; Jie Cao; Jing Chen; Jianxin Li; Jichun Chen; Xu Ji; Dongsheng Hu; Xushan Wang; De-Pei Liu; Jiang He
Journal:  Am J Epidemiol       Date:  2012-10-01       Impact factor: 4.897

Review 7.  The influence of heart failure self-care on health outcomes: hypothetical cardioprotective mechanisms.

Authors:  Christopher S Lee; Nancy C Tkacs; Barbara Riegel
Journal:  J Cardiovasc Nurs       Date:  2009 May-Jun       Impact factor: 2.083

8.  Enalapril protects against myocardial ischemia/reperfusion injury in a swine model of cardiac arrest and resuscitation.

Authors:  Guoxing Wang; Qian Zhang; Wei Yuan; Junyuan Wu; Chunsheng Li
Journal:  Int J Mol Med       Date:  2016-09-15       Impact factor: 4.101

9.  Increased Reactive Oxygen Species Generation Contributes to the Atherogenic Activity of the B2 Bradykinin Receptor.

Authors:  Alexander Perhal; Stefan Wolf; Yahya F Jamous; Andreas Langer; Joshua Abd Alla; Ursula Quitterer
Journal:  Front Med (Lausanne)       Date:  2019-02-21
  9 in total

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