OBJECTIVE: To identify genotypes and gene-environment interactions, which may explain ethnic differences on lipid profile in Black and White youth. DESIGN, SETTING, PARTICIPANTS: Healthy adolescents and young adults (N=413, 18.6 +/-2.8 yrs, 44% Black, 53% Male) drawn from a cardiovascular study. MAIN OUTCOME MEASURES: Total cholesterol (TC), high-density lipoprotein cholesterol (HDLC), and triglyceride (TG) concentrations were obtained from frozen plasma. The ApoB Glu4154Lys, LDL receptor (LDLR) T1773C, PPARgamma Pro12Ala, and TNFalpha -308G/A polymorphisms were genotyped. Analyses adjusted for age, sex, ethnicity, body mass index (BMI), socioeconomic status (SES), and interactions. RESULTS: The ApoB Glu4154Lys polymorphism interacted with obesity and age to predict TC levels. As BMI increased, 4154Lys ApoB allele carriers had higher TC levels than 4154Glu homozygotes (difference=0.23 mmol/L at BMI=30 kg/m2, 0.54 at BMI=40, P<.05). Juvenile, but not adult, ApoB 4154Lys allele carriers had higher TC (0.34 mmol/L, P<.01). Male -308A TNFalpha allele carriers had lower HDLC (0.10 mmol/L, P<.01). Carriers of the T1 773 LDLR allele had higher TG (0.26 mmol/ L, P<.01). No effect of the PPARgamma Pro12Ala polymorphism was found; the 12Ala PPARgamma allele was rare among Blacks (2%). CONCLUSIONS: The ApoB, TNFalpha, and LDLR candidate genes influenced lipid profiles in youth independent of environmental factors. The T1773 LDLR allele, which is rare among Blacks (7%), may contribute to lower TG in Blacks. The -308A TNFalpha allele may contribute to lower HDLC in males. These gene effects and gene-environment interactions may inform prevention and treatment of atherosclerosis.
OBJECTIVE: To identify genotypes and gene-environment interactions, which may explain ethnic differences on lipid profile in Black and White youth. DESIGN, SETTING, PARTICIPANTS: Healthy adolescents and young adults (N=413, 18.6 +/-2.8 yrs, 44% Black, 53% Male) drawn from a cardiovascular study. MAIN OUTCOME MEASURES: Total cholesterol (TC), high-density lipoprotein cholesterol (HDLC), and triglyceride (TG) concentrations were obtained from frozen plasma. The ApoB Glu4154Lys, LDL receptor (LDLR) T1773C, PPARgammaPro12Ala, and TNFalpha-308G/A polymorphisms were genotyped. Analyses adjusted for age, sex, ethnicity, body mass index (BMI), socioeconomic status (SES), and interactions. RESULTS: The ApoB Glu4154Lys polymorphism interacted with obesity and age to predict TC levels. As BMI increased, 4154Lys ApoB allele carriers had higher TC levels than 4154Glu homozygotes (difference=0.23 mmol/L at BMI=30 kg/m2, 0.54 at BMI=40, P<.05). Juvenile, but not adult, ApoB 4154Lys allele carriers had higher TC (0.34 mmol/L, P<.01). Male -308A TNFalpha allele carriers had lower HDLC (0.10 mmol/L, P<.01). Carriers of the T1 773 LDLR allele had higher TG (0.26 mmol/ L, P<.01). No effect of the PPARgammaPro12Ala polymorphism was found; the 12Ala PPARgamma allele was rare among Blacks (2%). CONCLUSIONS: The ApoB, TNFalpha, and LDLR candidate genes influenced lipid profiles in youth independent of environmental factors. The T1773 LDLR allele, which is rare among Blacks (7%), may contribute to lower TG in Blacks. The -308A TNFalpha allele may contribute to lower HDLC in males. These gene effects and gene-environment interactions may inform prevention and treatment of atherosclerosis.
Authors: Charles X Kim; Kent R Bailey; George G Klee; Allison A Ellington; Guanghui Liu; Thomas H Mosley; Hamid Rehman; Iftikhar J Kullo Journal: PLoS One Date: 2010-02-05 Impact factor: 3.240
Authors: Gabriella Andreotti; Idan Menashe; Jinbo Chen; Shih-Chen Chang; Asif Rashid; Yu-Tang Gao; Tian-Quan Han; Lori C Sakoda; Stephen Chanock; Philip S Rosenberg; Ann W Hsing Journal: Eur J Epidemiol Date: 2009-11-04 Impact factor: 8.082
Authors: Phum Tachachartvanich; Sylvia S Sanchez; Scarlett L Gomez; Esther M John; Martyn T Smith; Laura Fejerman Journal: PLoS One Date: 2020-06-01 Impact factor: 3.240