Literature DB >> 16259114

Tissue microarrays from HOPE-fixed specimens allow for enhanced high throughput molecular analyses in paraffin-embedded material.

Torsten Goldmann1, Daniel Drömann, Marouane Marzouki, Udo Schimmel, Karsten Debel, Detlev Branscheid, Tobias Zeiser, Jan Rupp, Johannes Gerdes, Peter Zabel, Ekkehard Vollmer.   

Abstract

In this study, we describe a technique that allows for the production and the use of tissue microarrays (TMA) from HOPE-fixed, paraffin-embedded specimens. The combination of these two technologies unites the advantages of the high throughput aspects in TMA, with good preservation of nucleic acids, proteins, and morphology of HOPE-fixed tissues, thus substantially widening the capabilities presently available for molecular studies in paraffin-embedded tissues.

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Year:  2005        PMID： 16259114     DOI： 10.1016/j.prp.2005.07.006

Source DB:  PubMed          Journal:  Pathol Res Pract        ISSN： 0344-0338            Impact factor:   3.250


  9 in total

Review 1.  From tissue to molecular phenotyping: pre-analytical requirements heidelberg experience.

Authors:  Thomas R Muley; Felix Jf Herth; Philipp A Schnabel; Hendrik Dienemann; Michael Meister
Journal:  Transl Lung Cancer Res       Date:  2012-06

2.  HOPE-BAL: improved molecular diagnostics by application of a novel technique for fixation and paraffin embedding.

Authors:  Sebastian Marwitz; Mahdi Abdullah; Christina Vock; Jay S Fine; Sudha Visvanathan; Karoline I Gaede; Hans-Peter Hauber; Peter Zabel; Torsten Goldmann
Journal:  J Histochem Cytochem       Date:  2011-03-23       Impact factor: 2.479

3.  Generation and evaluation of a monoclonal antibody, designated MAdL, as a new specific marker for adenocarcinomas of the lung.

Authors:  H Schultz; S Marwitz; B Baron-Lühr; G Zissel; C Kugler; K F Rabe; P Zabel; E Vollmer; J Gerdes; T Goldmann
Journal:  Br J Cancer       Date:  2011-08-02       Impact factor: 7.640

4.  The HOPE fixation technique--a promising alternative to common prostate cancer biobanking approaches.

Authors:  Martin Braun; Roopika Menon; Pavel Nikolov; Robert Kirsten; Karen Petersen; David Schilling; Christina Schott; Sibylle Gündisch; Falko Fend; Karl-Friedrich Becker; Sven Perner
Journal:  BMC Cancer       Date:  2011-12-07       Impact factor: 4.430

5.  Enhanced molecular analyses by combination of the HOPE-technique and laser microdissection.

Authors:  Torsten Goldmann; Renate Burgemeister; Ulrich Sauer; Siegfried Loeschke; Dagmar Silvia Lang; Detlev Branscheid; Peter Zabel; Ekkehard Vollmer
Journal:  Diagn Pathol       Date:  2006-03-31       Impact factor: 2.644

6.  LED-FISH: Fluorescence microscopy based on light emitting diodes for the molecular analysis of Her-2/neu oncogene amplification.

Authors:  Dagmar S Lang; Tobias Zeiser; Holger Schultz; Florian Stellmacher; Ekkehard Vollmer; Peter Zabel; Torsten Goldmann
Journal:  Diagn Pathol       Date:  2008-12-16       Impact factor: 2.644

7.  A novel human ex vivo model for the analysis of molecular events during lung cancer chemotherapy.

Authors:  Dagmar S Lang; Daniel Droemann; Holger Schultz; Detlev Branscheid; Christian Martin; Anne R Ressmeyer; Peter Zabel; Ekkehard Vollmer; Torsten Goldmann
Journal:  Respir Res       Date:  2007-06-14

8.  Improved diagnostics targeting c-MET in non-small cell lung cancer: expression, amplification and activation?

Authors:  I Watermann; B Schmitt; F Stellmacher; J Müller; R Gaber; Ch Kugler; N Reinmuth; R M Huber; M Thomas; P Zabel; K F Rabe; D Jonigk; A Warth; E Vollmer; M Reck; T Goldmann
Journal:  Diagn Pathol       Date:  2015-07-28       Impact factor: 2.644

9.  KINFix--A formalin-free non-commercial fixative optimized for histological, immunohistochemical and molecular analyses of neurosurgical tissue specimens.

Authors:  Harald Stefanits; Michal Bienkowski; Markus Galanski; Goran Mitulovic; Thomas Ströbel; Ellen Gelpi; Teresa Ribalta; Helle Broholm; Christian Hartmann; Johan M Kros; Matthias Preusser; Johannes A Hainfellner
Journal:  Clin Neuropathol       Date:  2016 Jan-Feb       Impact factor: 1.368
  9 in total

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