| Literature DB >> 16258879 |
B Jülg1, F D Goebel.
Abstract
Chemokine receptors are essential for human immunodeficiency virus (HIV) cell entry. CXCR4 and CCR5 are the two most relevant receptors and by inhibition of each of them a delayed onset of disease could be achieved. As both receptors are used at different stages of disease due to the domination of different HIV strains, a dual blockage of CXCR4 and CCR5 could be highly valuable for inhibiting viral transmission and replication.Entities:
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Year: 2005 PMID： 16258879 DOI： 10.1007/s15010-005-6605-8
Source DB: PubMed Journal: Infection ISSN： 0300-8126 Impact factor: 3.553