| Literature DB >> 16258726 |
Janice L Walker1, Richard K Assoian.
Abstract
Integrins and growth factor receptors coordinately regulate proliferation in nontransformed cells. Coordinate signaling from these receptors controls the activation of the G1 phase cyclin-dependent kinases, largely by regulating levels of cyclin D1 and p27(kip1). Induction of cyclin D1 is one of the best understood examples of an integrin/growth factor receptor-regulated G1 phase target. This review focuses on the integrin-dependent signal transduction events that regulate the expression of cyclin D1 during G1 phase.Entities:
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Year: 2005 PMID: 16258726 DOI: 10.1007/s10555-005-5130-7
Source DB: PubMed Journal: Cancer Metastasis Rev ISSN: 0167-7659 Impact factor: 9.264