Literature DB >> 16257939

Racializing drug design: implications of pharmacogenomics for health disparities.

Sandra Soo-Jin Lee1.   

Abstract

Current practices of using "race" in pharmacogenomics research demands consideration of the ethical and social implications for understandings of group difference and for efforts to eliminate health disparities. This discussion focuses on an "infrastructure of racialization" created by current trajectories of research on genetic differences among racially identified groups, the use of race as a proxy for risk in clinical practice, and increasing interest in new market niches by the pharmaceutical industry. The confluence of these factors has resulted in the conflation of genes, disease, and race. I argue that public investment in pharmacogenomics requires careful consideration of current inequities in health status and social and ethical concerns over reifying race and issues of distributive justice.

Keywords:  Biomedical and Behavioral Research; Genetics and Reproduction; Health Care and Public Health

Mesh:

Year:  2005        PMID: 16257939      PMCID: PMC1449497          DOI: 10.2105/AJPH.2005.068676

Source DB:  PubMed          Journal:  Am J Public Health        ISSN: 0090-0036            Impact factor:   9.308


  33 in total

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Authors:  D L Veenstra; M K Higashi; K A Phillips
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3.  Racial profiling in medical research.

Authors:  R S Schwartz
Journal:  N Engl J Med       Date:  2001-05-03       Impact factor: 91.245

Review 4.  Ethical perspectives on pharmacogenomic profiling in the drug development process.

Authors:  Amalia M Issa
Journal:  Nat Rev Drug Discov       Date:  2002-04       Impact factor: 84.694

5.  Whole-genome patterns of common DNA variation in three human populations.

Authors:  David A Hinds; Laura L Stuve; Geoffrey B Nilsen; Eran Halperin; Eleazar Eskin; Dennis G Ballinger; Kelly A Frazer; David R Cox
Journal:  Science       Date:  2005-02-18       Impact factor: 47.728

6.  Personalized medicine: revolutionizing drug discovery and patient care.

Authors:  G S Ginsburg; J J McCarthy
Journal:  Trends Biotechnol       Date:  2001-12       Impact factor: 19.536

7.  Projecting future drug expenditures--2000.

Authors:  B Mehl; J P Santell
Journal:  Am J Health Syst Pharm       Date:  2000-01-15       Impact factor: 2.637

Review 8.  Pharmacogenomics: the promise of personalized medicine.

Authors:  L Mancinelli; M Cronin; W Sadée
Journal:  AAPS PharmSci       Date:  2000

Review 9.  Pharmacogenetics--legal, ethical and regulatory considerations.

Authors:  R March; K Cheeseman; M Doherty
Journal:  Pharmacogenomics       Date:  2001-11       Impact factor: 2.533

10.  Drug-related morbidity and mortality: updating the cost-of-illness model.

Authors:  F R Ernst; A J Grizzle
Journal:  J Am Pharm Assoc (Wash)       Date:  2001 Mar-Apr
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  28 in total

1.  Racial medicine: here to stay? The success of the International HapMap Project and other initiatives may help to overcome racial profiling in medicine, but old habits die hard.

Authors:  Katrin Weigmann
Journal:  EMBO Rep       Date:  2006-03       Impact factor: 8.807

2.  The ambiguous meanings of the racial/ethnic categories routinely used in human genetics research.

Authors:  Linda M Hunt; Mary S Megyesi
Journal:  Soc Sci Med       Date:  2007-10-23       Impact factor: 4.634

3.  Medicine. Racing forward: the Genomics and Personalized Medicine Act.

Authors:  Sandra Soo-Jin Lee; Ashwin Mudaliar
Journal:  Science       Date:  2009-01-16       Impact factor: 47.728

4.  Genes, race and research ethics: who's minding the store?

Authors:  L M Hunt; M S Megyesi
Journal:  J Med Ethics       Date:  2008-06       Impact factor: 2.903

5.  The case for Eliminating Disparities in Clinical Trials.

Authors:  Daniel Goldberg
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6.  Challenges and Considerations Related to Studying Dementia in Blacks/African Americans.

Authors:  Eseosa T Ighodaro; Peter T Nelson; Walter A Kukull; Frederick A Schmitt; Erin L Abner; Allison Caban-Holt; Shoshana H Bardach; Derrick C Hord; Crystal M Glover; Gregory A Jicha; Linda J Van Eldik; Alexander X Byrd; Anita Fernander
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7.  Ancestry, Temporality, and Potentiality: Engaging Cancer Genetics in Southern Brazil.

Authors:  Sahra Gibbon
Journal:  Curr Anthropol       Date:  2013-10

8.  Homogeneity and heterogeneity as situational properties: producing--and moving beyond?--race in post-genomic science.

Authors:  Janet K Shim; Katherine Weatherford Darling; Martine D Lappe; L Katherine Thomson; Sandra Soo-Jin Lee; Robert A Hiatt; Sara L Ackerman
Journal:  Soc Stud Sci       Date:  2014-08       Impact factor: 3.885

Review 9.  Within and beyond the communal turn to informed consent in industry-sponsored pharmacogenetics research: merits and challenges of community advisory boards.

Authors:  Hojjat Soofi; Evert van Leeuwen
Journal:  J Community Genet       Date:  2016-08-05

10.  Race and ancestry in biomedical research: exploring the challenges.

Authors:  Timothy Caulfield; Stephanie M Fullerton; Sarah E Ali-Khan; Laura Arbour; Esteban G Burchard; Richard S Cooper; Billie-Jo Hardy; Simrat Harry; Robyn Hyde-Lay; Jonathan Kahn; Rick Kittles; Barbara A Koenig; Sandra Sj Lee; Michael Malinowski; Vardit Ravitsky; Pamela Sankar; Stephen W Scherer; Béatrice Séguin; Darren Shickle; Guilherme Suarez-Kurtz; Abdallah S Daar
Journal:  Genome Med       Date:  2009-01-21       Impact factor: 11.117

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