Literature DB >> 16257471

Co-expression of the 5-HT(3B) subunit with the 5-HT(3A) receptor reduces alcohol sensitivity.

Volodya Hayrapetyan1, Monica Jenschke, Glenn H Dillon, Tina K Machu.   

Abstract

Allosteric modulation of mouse 5-Hydroxytryptamine(3A) (5-HT(3A)) and 5-HT(3A/B) receptor function by ethanol and trichloroethanol (TCEt) was assessed in HEK293 cells with whole cell patch-clamp electrophysiological recordings. Ethanol enhanced 5-HT(3A) receptor function, but had no effect on mouse 5-HT(3A/B) receptor mediated currents. The enhancing action of trichloroethanol (TCEt) on mouse 5-HT(3A/B) receptor function was much less than that observed in the mouse 5-HT(3A) receptor. Where alcohol-induced increases in peak amplitude were observed, the slope of the 20-80% rising phase of current onset was also enhanced, suggesting that increases in activation rate may be one mechanism through which alcohols enhance function of the 5-HT(3) receptors.

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Year:  2005        PMID： 16257471     DOI： 10.1016/j.molbrainres.2005.09.011

Source DB:  PubMed          Journal:  Brain Res Mol Brain Res        ISSN： 0169-328X


  12 in total

1.  Effects of ethanol on adenosine 5'-triphosphate-gated purinergic and 5-hydroxytryptamine receptors.

Authors:  Daryl L Davies; Liana Asatryan; Sacha T Kuo; John J Woodward; Brian F King; Ronald L Alkana; Cheng Xiao; Jiang Hong Ye; Hui Sun; Li Zhang; Xiang-Qun Hu; Volodya Hayrapetyan; David M Lovinger; Tina K Machu
Journal:  Alcohol Clin Exp Res       Date:  2006-02       Impact factor: 3.455

Review 2.  Acute alcohol action and desensitization of ligand-gated ion channels.

Authors:  Alex M Dopico; David M Lovinger
Journal:  Pharmacol Rev       Date:  2009-03-06       Impact factor: 25.468

3.  Enhanced 5-HT(2A) receptor status in the hypothalamus and corpus striatum of ethanol-treated rats.

Authors:  K G Akash; K S Balarama; C S Paulose
Journal:  Cell Mol Neurobiol       Date:  2008-04-19       Impact factor: 5.046

Review 4.  Allosteric modulation of the 5-HT(3) receptor.

Authors:  Paul A Davies
Journal:  Curr Opin Pharmacol       Date:  2011-02-20       Impact factor: 5.547

Review 5.  The 5-HT3 receptor as a therapeutic target.

Authors:  Andrew J Thompson; Sarah C R Lummis
Journal:  Expert Opin Ther Targets       Date:  2007-04       Impact factor: 6.902

Review 6.  Therapeutics of 5-HT3 receptor antagonists: current uses and future directions.

Authors:  Tina K Machu
Journal:  Pharmacol Ther       Date:  2011-02-26       Impact factor: 12.310

7.  Ethanol stabilizes the open state of single 5-hydroxytryptamine(3A)(QDA) receptors.

Authors:  Paula L Feinberg-Zadek; Paul A Davies
Journal:  J Pharmacol Exp Ther       Date:  2010-03-03       Impact factor: 4.030

8.  HTR3B is associated with alcoholism with antisocial behavior and alpha EEG power--an intermediate phenotype for alcoholism and co-morbid behaviors.

Authors:  Francesca Ducci; Mary-Anne Enoch; Qiaoping Yuan; Pei-Hong Shen; Kenneth V White; Colin Hodgkinson; Bernard Albaugh; Matti Virkkunen; David Goldman
Journal:  Alcohol       Date:  2009-02       Impact factor: 2.405

Review 9.  The role of 5-HT3 receptors in drug abuse and as a target for pharmacotherapy.

Authors:  E A Engleman; Z A Rodd; R L Bell; J M Murphy
Journal:  CNS Neurol Disord Drug Targets       Date:  2008-11       Impact factor: 4.388

10.  Mutations of L293 in transmembrane two of the mouse 5-hydroxytryptamine3A receptor alter gating and alcohol modulatory actions.

Authors:  Xiang-Qun Hu; Volodya Hayrapetyan; Jay J Gadhiya; Heather E Rhubottom; David M Lovinger; Tina K Machu
Journal:  Br J Pharmacol       Date:  2006-05       Impact factor: 8.739
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