Literature DB >> 16257201

Privileged structure-based quinazolinone natural product-templated libraries: identification of novel tubulin polymerization inhibitors.

Ji-Feng Liu1, Christopher J Wilson, Ping Ye, Kevin Sprague, Katie Sargent, Ying Si, Galina Beletsky, Daniel Yohannes, Shi-Chung Ng.   

Abstract

A focused quinazolinone natural product-templated library was designed and synthesized. Compounds from this privileged structure-based library were identified as antimitotic agents acting through destabilization of tubulin polymerization. The results suggested that 2 could be a privileged substructure.

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Year:  2005        PMID： 16257201     DOI： 10.1016/j.bmcl.2005.10.022

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  4 in total

1.  One-pot, regiospecific assembly of (E)-benzamidines from δ- and γ-amino acids via an intramolecular aminoquinazolinone rearrangement.

Authors:  Chad E Schroeder; Sarah A Neuenswander; Tuanli Yao; Jeffrey Aubé; Jennifer E Golden
Journal:  Org Biomol Chem       Date:  2016-04-06       Impact factor: 3.876

2.  Synthesis and biological evaluation studies of novel quinazolinone derivatives as antibacterial and anti-inflammatory agents.

Authors:  Mohamed F Zayed; Memy H Hassan
Journal:  Saudi Pharm J       Date:  2013-04-06       Impact factor: 4.330

3.  Synthesis and cytotoxic evaluation of some new 4(3H)-quinazolinones on HeLa cell line.

Authors:  G A Khodarahmi; M Shamshiri; F Hassanzadeh
Journal:  Res Pharm Sci       Date:  2012-04

4.  Identification of the first inhibitor of the GBP1:PIM1 interaction. Implications for the development of a new class of anticancer agents against paclitaxel resistant cancer cells.

Authors:  Mirko Andreoli; Marco Persico; Ajay Kumar; Nausicaa Orteca; Vineet Kumar; Antonella Pepe; Sakkarapalayam Mahalingam; Antonio E Alegria; Lella Petrella; Laima Sevciunaite; Alessia Camperchioli; Marisa Mariani; Antonio Di Dato; Ettore Novellino; Giovanni Scambia; Sanjay V Malhotra; Cristiano Ferlini; Caterina Fattorusso
Journal:  J Med Chem       Date:  2014-09-26       Impact factor: 7.446
  4 in total

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