| Literature DB >> 16256980 |
Masanobu Yoshikawa1, Hidehiro Andoh, Kenji Ito, Toshiyasu Suzuki, Mitsuru Kawaguchi, Hiroyuki Kobayashi, Tetsuo Oka, Atsushi Hashimoto.
Abstract
To obtain further insight into the interactions between the N-methyl-D-aspartate receptor and opioid receptor systems, we have investigated the effects of the acute treatment of morphine on the expression of serine racemase and D-amino acid oxidase mRNAs in several brain areas of rats. The morphine administration produced a dose-dependent and transient elevation in the levels of serine racemase and D-amino acid oxidase mRNAs in all the brain areas. The present results are the first to suggest an interaction between the expression of the mRNAs for the D-serine-related enzymes and the opioid receptor activation.Entities:
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Year: 2005 PMID： 16256980 DOI： 10.1016/j.ejphar.2005.09.001
Source DB: PubMed Journal: Eur J Pharmacol ISSN： 0014-2999 Impact factor: 4.432