| Literature DB >> 16256730 |
Sophie Cotteret1, Jonathan Chernoff.
Abstract
The protein kinase Aurora-A orchestrates key aspects of cell division, but its regulation has remained a major puzzle. That puzzle is now one step closer to being solved thanks to a recent paper by Zhao et al. appearing in the October 28(th) issue of Molecular Cell. In this work, the authors show that p21-activated kinases (Paks), previously best known for their role in cytoskeletal and transcriptional signaling pathways, also play an important role in centrosome dynamics via phosphorylation and activation of Aurora-A.Entities:
Mesh：
Substances：
Year: 2005 PMID： 16256730 DOI： 10.1016/j.devcel.2005.10.005
Source DB: PubMed Journal: Dev Cell ISSN： 1534-5807 Impact factor: 12.270