| Literature DB >> 16256413 |
Marisa Cristina Leite Santos Genelhu1, Helenice Gobbi, Fernando Augusto Soares, Antônio Hugo José Froes de Marques Campos, Carlos Alberto Ribeiro, Geovanni Dantas Cassali.
Abstract
Alteration of the p63 protein expression has been associated with several human cancers including salivary gland tumors. We sought to assess the p63 expression in pleomorphic adenomas (PA) and carcinoma ex-pleomorphic adenomas (Ca ex-PA), since this protein has been related to myoepithelial phenotype and the biological behavior of cancer. Ten samples of PA and ten of Ca ex-PA were submitted to immunohistochemistry using a monoclonal anti-p63 antibody, clone 4A4. p63 was regularly expressed in myoepithelial cells' nuclei of the normal glandular parenchyma and in PA, but it was completely absent in five out of the ten samples of Ca ex-PA. (P < 0.05 by Fisher's exact test). Apparently, only those cases depicting some myoepithelial differentiation were positive. Our data suggest that loss of myoepithelial differentiation is important in the evolution of Ca ex-PA, and corroborate the hypothesis that p63 antigen may be a useful marker of myoepithelial cells in salivary glands neoplasms.Entities:
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Year: 2005 PMID： 16256413 DOI： 10.1016/j.oraloncology.2005.06.026
Source DB: PubMed Journal: Oral Oncol ISSN： 1368-8375 Impact factor: 5.337