Literature DB >> 1625574

IRE1 encodes a putative protein kinase containing a membrane-spanning domain and is required for inositol phototrophy in Saccharomyces cerevisiae.

J Nikawa1, S Yamashita.   

Abstract

A novel gene, IRE1, of Saccharomyces cerevisiae was cloned through genetic complementation of a myoinositol auxotrophic mutant. The predicted amino acid sequence indicated that IRE1 encodes a protein of 126983 Da with two highly hydrophobic regions, probably a signal sequence and a membrane-spanning region. The carboxy-terminal region of IRE1 showed close sequence similarity to the catalytic domains of protein kinases. Disruption of the IRE1 locus caused myo-inositol auxotrophy. The IRE1 product is very likely a protein kinase required for myo-inositol synthesis.

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Year:  1992        PMID： 1625574     DOI： 10.1111/j.1365-2958.1992.tb00864.x

Source DB:  PubMed          Journal:  Mol Microbiol        ISSN： 0950-382X            Impact factor:   3.501


  83 in total

1.  Basis for regulated RNA cleavage by functional analysis of RNase L and Ire1p.

Authors:  B Dong; M Niwa; P Walter; R H Silverman
Journal:  RNA       Date:  2001-03       Impact factor: 4.942

2.  The REG1 gene product is required for repression of INO1 and other inositol-sensitive upstream activating sequence-containing genes of yeast.

Authors:  Q Ouyang; M Ruiz-Noriega; S A Henry
Journal:  Genetics       Date:  1999-05       Impact factor: 4.562

3.  The unfolded protein response regulates glutamate receptor export from the endoplasmic reticulum.

Authors:  Jaegal Shim; Tohru Umemura; Erika Nothstein; Christopher Rongo
Journal:  Mol Biol Cell       Date:  2004-08-18       Impact factor: 4.138

4.  Yet1p and Yet3p, the yeast homologs of BAP29 and BAP31, interact with the endoplasmic reticulum translocation apparatus and are required for inositol prototrophy.

Authors:  Joshua D Wilson; Charles Barlowe
Journal:  J Biol Chem       Date:  2010-04-08       Impact factor: 5.157

Review 5.  Phosphatidic acid plays a central role in the transcriptional regulation of glycerophospholipid synthesis in Saccharomyces cerevisiae.

Authors:  George M Carman; Susan A Henry
Journal:  J Biol Chem       Date:  2007-11-02       Impact factor: 5.157

6.  Mutual cross talk between the regulators Hac1 of the unfolded protein response and Gcn4 of the general amino acid control of Saccharomyces cerevisiae.

Authors:  Britta Herzog; Blagovesta Popova; Antonia Jakobshagen; Hedieh Shahpasandzadeh; Gerhard H Braus
Journal:  Eukaryot Cell       Date:  2013-06-21

7.  IN02, a positive regulator of lipid biosynthesis, is essential for the formation of inducible membranes in yeast.

Authors:  Laura Block-Alper; Paul Webster; Xianghong Zhou; Lubica Supeková; Wing Hung Wong; Peter G Schultz; David I Meyer
Journal:  Mol Biol Cell       Date:  2002-01       Impact factor: 4.138

8.  The ire1 and ptc2 genes involved in the unfolded protein response pathway in the filamentous fungus Trichoderma reesei.

Authors:  M Valkonen; M Penttilä; M Saloheimo
Journal:  Mol Genet Genomics       Date:  2004-10-08       Impact factor: 3.291

9.  Role of the unfolded protein response pathway in regulation of INO1 and in the sec14 bypass mechanism in Saccharomyces cerevisiae.

Authors:  Hak J Chang; Elizabeth W Jones; Susan A Henry
Journal:  Genetics       Date:  2002-09       Impact factor: 4.562

10.  Saccharomyces cerevisiae IRE2/HAC1 is involved in IRE1-mediated KAR2 expression.

Authors:  J Nikawa; M Akiyoshi; S Hirata; T Fukuda
Journal:  Nucleic Acids Res       Date:  1996-11-01       Impact factor: 16.971
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