Literature DB >> 16254802

Using computational modeling to drive the development of targeted therapeutics.

Ulrik B Nielsen1, Brigit Schoeberl.   

Abstract

Computational biology is impacting drug design and has the potential to revolutionize the drug development process. Here, we describe how data-driven computational models can optimize the design of targeted therapeutics to yield improved safety and efficacy. We propose that, in the future, this approach will improve drug discovery, clinical development, diagnosis and treatment.

Mesh：

Year:  2005        PMID： 16254802

Source DB:  PubMed          Journal:  IDrugs        ISSN： 1369-7056


  5 in total

1.  In Silico Augmentation of the Drug Development Pipeline: Examples from the study of Acute Inflammation.

Authors:  Gary An; John Bartels; Yoram Vodovotz
Journal:  Drug Dev Res       Date:  2011-03-01       Impact factor: 4.360

2.  Systems biology by the rules: hybrid intelligent systems for pathway modeling and discovery.

Authors:  William J Bosl
Journal:  BMC Syst Biol       Date:  2007-02-15

3.  Functional aspects of the EGF-induced MAP kinase cascade: a complex self-organizing system approach.

Authors:  Efstratios K Kosmidis; Vasiliki Moschou; Georgios Ziogas; Ioannis Boukovinas; Maria Albani; Nikolaos A Laskaris
Journal:  PLoS One       Date:  2014-11-05       Impact factor: 3.240

4.  Effect of phosphorylation on EGFR dimer stability probed by single-molecule dynamics and FRET/FLIM.

Authors:  Oana Coban; Laura C Zanetti-Dominguez; Daniel R Matthews; Daniel J Rolfe; Gregory Weitsman; Paul R Barber; Jody Barbeau; Viviane Devauges; Florian Kampmeier; Martyn Winn; Borivoj Vojnovic; Peter J Parker; Keith A Lidke; Diane S Lidke; Simon M Ameer-Beg; Marisa L Martin-Fernandez; Tony Ng
Journal:  Biophys J       Date:  2015-03-10       Impact factor: 4.033

5.  Deciphering the mechanism behind Fibroblast Growth Factor (FGF) induced biphasic signal-response profiles.

Authors:  Jitendra Kanodia; Diana Chai; Jannik Vollmer; Jaeyeon Kim; Andreas Raue; Greg Finn; Birgit Schoeberl
Journal:  Cell Commun Signal       Date:  2014-05-15       Impact factor: 5.712
  5 in total

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