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Literature DB >> 16254380

Retroviral restriction factor TRIM5alpha is a trimer.

Claudia C Mische¹, Hassan Javanbakht, Byeongwoon Song, Felipe Diaz-Griffero, Matthew Stremlau, Bettina Strack, Zhihai Si, Joseph Sodroski.

Abstract

The retrovirus restriction factor TRIM5alpha targets the viral capsid soon after entry. Here we show that the TRIM5alpha protein oligomerizes into trimers. The TRIM5alpha coiled-coil and B30.2(SPRY) domains make important contributions to the formation and/or stability of the trimers. A functionally defective TRIM5alpha mutant with the RING and B-box 2 domains deleted can form heterotrimers with wild-type TRIM5alpha, accounting for the observed dominant-negative activity of the mutant protein. Trimerization potentially allows TRIM5alpha to interact with threefold pseudosymmetrical structures on retroviral capsids.

Entities: Gene Species

Mesh：

Substances：

Year: 2005 PMID： 16254380 PMCID： PMC1280198 DOI： 10.1128/JVI.79.22.14446-14450.2005

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

41 in total

1. Image reconstructions of helical assemblies of the HIV-1 CA protein.

Authors: S Li; C P Hill; W I Sundquist; J T Finch
Journal: Nature Date: 2000-09-21 Impact factor: 49.962

2. A conserved mechanism of retrovirus restriction in mammals.

Authors: G Towers; M Bock; S Martin; Y Takeuchi; J P Stoye; O Danos
Journal: Proc Natl Acad Sci U S A Date: 2000-10-24 Impact factor: 11.205

3. Hetero-oligomerization among the TIF family of RBCC/TRIM domain-containing nuclear cofactors: a potential mechanism for regulating the switch between coactivation and corepression.

Authors: Hongzhuang Peng; Irina Feldman; Frank J Rauscher
Journal: J Mol Biol Date: 2002-07-12 Impact factor: 5.469

4. Abrogation of postentry restriction of HIV-1-based lentiviral vector transduction in simian cells.

Authors: Neeltje A Kootstra; Carsten Munk; Nina Tonnu; Nathaniel R Landau; Inder M Verma
Journal: Proc Natl Acad Sci U S A Date: 2003-01-23 Impact factor: 11.205

5. Human and simian immunodeficiency virus capsid proteins are major viral determinants of early, postentry replication blocks in simian cells.

Authors: Christopher M Owens; Peter C Yang; Heinrich Göttlinger; Joseph Sodroski
Journal: J Virol Date: 2003-01 Impact factor: 5.103

Retroviral restriction factor TRIM5alpha is a trimer.

1. Image reconstructions of helical assemblies of the HIV-1 CA protein.

2. A conserved mechanism of retrovirus restriction in mammals.

3. Hetero-oligomerization among the TIF family of RBCC/TRIM domain-containing nuclear cofactors: a potential mechanism for regulating the switch between coactivation and corepression.

4. Abrogation of postentry restriction of HIV-1-based lentiviral vector transduction in simian cells.

5. Human and simian immunodeficiency virus capsid proteins are major viral determinants of early, postentry replication blocks in simian cells.

6. A dominant block to HIV-1 replication at reverse transcription in simian cells.

7. Restriction of lentivirus in monkeys.

8. Cellular inhibitors with Fv1-like activity restrict human and simian immunodeficiency virus tropism.

9. Target cell cyclophilin A modulates human immunodeficiency virus type 1 infectivity.

10. The tripartite motif family identifies cell compartments.

1. Modulation of TRIM5alpha activity in human cells by alternatively spliced TRIM5 isoforms.

2. Hexagonal assembly of a restricting TRIM5alpha protein.

3. Human Trim5α has additional activities that are uncoupled from retroviral capsid recognition.

4. Balancing selection and the evolution of functional polymorphism in Old World monkey TRIM5alpha.

5. The tripartite motif of nuclear factor 7 is required for its association with transcriptional units.

Review 6. Cyclophilin A, TRIM5, and resistance to human immunodeficiency virus type 1 infection.

7. The retroviral restriction factor TRIM5alpha.

Review 8. Molecular evolution of the antiretroviral TRIM5 gene.

9. Dynamic movements of Ro52 cytoplasmic bodies along microtubules.

10. Determinants for the rhesus monkey TRIM5alpha-mediated block of the late phase of HIV-1 replication.