BACKGROUND AND PURPOSE: Stroke is a leading cause of disability and death in the United States, yet limited therapeutic options exist. The need for novel neuroprotective agents has spurred efforts to understand the intracellular signaling pathways that mediate cellular response to stroke. Protein kinase C (PKC) plays a central role in mediating ischemic and reperfusion damage in multiple tissues, including the brain. However, because of conflicting reports, it remains unclear whether PKC is involved in cell survival signaling, or mediates detrimental processes. SUMMARY OF REVIEW: This review will examine the role of PKC activity in stroke. In particular, we will focus on more recent insights into the PKC isozyme-specific responses in neuronal preconditioning and in ischemia and reperfusion-induced stress. CONCLUSIONS: Examination of PKC isozyme activities during stroke demonstrates the clinical promise of PKC isozyme-specific modulators for the treatment of cerebral ischemia.
BACKGROUND AND PURPOSE:Stroke is a leading cause of disability and death in the United States, yet limited therapeutic options exist. The need for novel neuroprotective agents has spurred efforts to understand the intracellular signaling pathways that mediate cellular response to stroke. Protein kinase C (PKC) plays a central role in mediating ischemic and reperfusion damage in multiple tissues, including the brain. However, because of conflicting reports, it remains unclear whether PKC is involved in cell survival signaling, or mediates detrimental processes. SUMMARY OF REVIEW: This review will examine the role of PKC activity in stroke. In particular, we will focus on more recent insights into the PKC isozyme-specific responses in neuronal preconditioning and in ischemia and reperfusion-induced stress. CONCLUSIONS: Examination of PKC isozyme activities during stroke demonstrates the clinical promise of PKC isozyme-specific modulators for the treatment of cerebral ischemia.
Authors: Zhenjun Tan; Ryan C Turner; Rachel L Leon; Xinlan Li; Jarin Hongpaisan; Wen Zheng; Aric F Logsdon; Zachary J Naser; Daniel L Alkon; Charles L Rosen; Jason D Huber Journal: Stroke Date: 2013-10-30 Impact factor: 7.914
Authors: Usha Gundimeda; Thomas H McNeill; Albert A Elhiani; Jason E Schiffman; David R Hinton; Rayudu Gopalakrishna Journal: J Biol Chem Date: 2012-08-09 Impact factor: 5.157
Authors: Xiaoyun Sun; Grant R Budas; Lijun Xu; George E Barreto; Daria Mochly-Rosen; Rona G Giffard Journal: J Neurosci Res Date: 2013-02-21 Impact factor: 4.164