Literature DB >> 16253763

Regulation of human peptide transporter 1 (PEPT1) in gastric cancer cells by anticancer drugs.

Mayumi Inoue1, Tomohiro Terada, Masahiro Okuda, Ken-Ichi Inui.   

Abstract

Human peptide transporter 1 (PEPT1) mediates the cellular uptake of di- and tripeptides and peptide-like drugs in the small intestine. In the present study, we examined the regulation of PEPT1 by anticancer drugs in the gastric cancer cell line MKN45. PEPT1 was expressed and functioned in MKN45 cells. The transport activity and mRNA expression of the facilitative glucose transporter 1 (GLUT1) were significantly decreased by 5-fluorouracil treatment, but those of PEPT1 were slightly increased. Cisplatin treatment affected neither PEPT1 nor GLUT1 activity. In conclusion, PEPT1 expressed in MKN45 cells are resistant against the cellular injury induced by 5-fluorouracil and cisplatin.

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Year:  2005        PMID： 16253763     DOI： 10.1016/j.canlet.2004.12.023

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  11 in total

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Journal:  Cell Mol Gastroenterol Hepatol       Date:  2016-05

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Authors:  Hui Huang; Junwei Wang; Shibin Chen; HongJiang He; Yu Shang; Xiaorong Guo; Ge Lou; Jingjing Ji; Mian Guo; Hong Chen; Shan Yu
Journal:  Front Genet       Date:  2021-06-08       Impact factor: 4.599
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