OBJECTIVE: The aim of the study was to examine the relationship between antithyroid antibodies, depression, and anxiety in a large population. METHODS: In a population of 30,175 individuals aged 40-84 years, thyroid-stimulating hormone (TSH) was assessed in all women and in 50% of the men. Thyroid peroxidase autoantibodies (TPOAb) were measured in almost all samples with TSH > or = 4.0 mU/L (n = 1700) and in randomly selected samples without thyroid disease or biochemical dysfunction (n = 745). The levels of anxiety and depression were screened using the Hospital Anxiety and Depression Scale (HADS). Relations were investigated with multiple logistic regression analyses. RESULTS: In individuals with normal TSH and without known thyroid disorder, the prevalence of TPOAb was 14.2% in women and 4.3% in men. The prevalence of TPOAb in participants with biochemical thyroid dysfunction was 59.0% in women and 38.9% in men. No associations were found between thyroid autoimmunity and depression or anxiety, neither crude nor adjusted for age, gender, TSH, and thyroxine (T4). CONCLUSION: Thyroid autoimmunity is a common disorder in the population, mainly affecting females. In a population-based study, no associations were found between antithyroid antibodies and depression or anxiety.
OBJECTIVE: The aim of the study was to examine the relationship between antithyroid antibodies, depression, and anxiety in a large population. METHODS: In a population of 30,175 individuals aged 40-84 years, thyroid-stimulating hormone (TSH) was assessed in all women and in 50% of the men. Thyroid peroxidase autoantibodies (TPOAb) were measured in almost all samples with TSH > or = 4.0 mU/L (n = 1700) and in randomly selected samples without thyroid disease or biochemical dysfunction (n = 745). The levels of anxiety and depression were screened using the Hospital Anxiety and Depression Scale (HADS). Relations were investigated with multiple logistic regression analyses. RESULTS: In individuals with normal TSH and without known thyroid disorder, the prevalence of TPOAb was 14.2% in women and 4.3% in men. The prevalence of TPOAb in participants with biochemical thyroid dysfunction was 59.0% in women and 38.9% in men. No associations were found between thyroid autoimmunity and depression or anxiety, neither crude nor adjusted for age, gender, TSH, and thyroxine (T4). CONCLUSION:Thyroid autoimmunity is a common disorder in the population, mainly affecting females. In a population-based study, no associations were found between antithyroid antibodies and depression or anxiety.
Authors: Marina Djurovic; Alberto M Pereira; Johannes W A Smit; Olga Vasovic; Svetozar Damjanovic; Zvezdana Jemuovic; Dragan Pavlovic; Dragana Miljic; Sandra Pekic; Marko Stojanovic; Milika Asanin; Gordana Krljanac; Milan Petakov Journal: Endocrine Date: 2018-06-29 Impact factor: 3.633
Authors: Eva-Maria Siegmann; Helge H O Müller; Caroline Luecke; Alexandra Philipsen; Johannes Kornhuber; Teja Wolfgang Grömer Journal: JAMA Psychiatry Date: 2018-06-01 Impact factor: 21.596