OBJECTIVE: To study whether the Oleanolic acid had curative effect on climacteric rats as an independent factor. METHODS: The experimental group was administrated with Oleanolic acid, while the positive group was given with Isoflavniphytoestrogeno, and the climacteric model and adolescent control groups were fed with 0.9% saline water. The effect of Oleanolic acid on rats was observed. In each group the levels of serum E2, SOD, MDA, GSH-Px were tested, the morphology of ovary and adrenal cortex were also studied. RESULTS: It was showed that Oleanolic acid could increase the levels of serum E2, SOD, GSH-Px (P < 0.05), decrease the level of MDA (P < 0.01) and improve the morphology and the functions of ovary and adrenal cortex. CONCLUSIONS: It is concluded that Oleanolic acid has curative effect independently on climacteric rats.
OBJECTIVE: To study whether the Oleanolic acid had curative effect on climacteric rats as an independent factor. METHODS: The experimental group was administrated with Oleanolic acid, while the positive group was given with Isoflavniphytoestrogeno, and the climacteric model and adolescent control groups were fed with 0.9% salinewater. The effect of Oleanolic acid on rats was observed. In each group the levels of serum E2, SOD, MDA, GSH-Px were tested, the morphology of ovary and adrenal cortex were also studied. RESULTS: It was showed that Oleanolic acid could increase the levels of serum E2, SOD, GSH-Px (P < 0.05), decrease the level of MDA (P < 0.01) and improve the morphology and the functions of ovary and adrenal cortex. CONCLUSIONS: It is concluded that Oleanolic acid has curative effect independently on climacteric rats.
Authors: Lian Fang; Wang Rui-Xia; Ma Feng-Mei; Sun Zhen-Gao; Wang Li-Hong; Shi Lei Journal: J Altern Complement Med Date: 2012-10-17 Impact factor: 2.579