Literature DB >> 16252076

The antioxidant anethole dithiolethione inhibits monoamine oxidase-B but not monoamine oxidase A activity in extracts of cultured astrocytes.

B Drukarch1, J Flier, C A M Jongenelen, G Andringa, A N M Schoffelmeer.   

Abstract

Anethole dithiolethione (ADT) is a clinically available, pluripotent antioxidant proposed as a neuroprotectant for Parkinson's disease (PD). Here, using extracts from cultured astrocytes, containing both monoamine oxidase (MAO) A and B activity, we demonstrate that ADT concentration-dependently inhibits MAO-B activity in a clinically relevant concentration range (0.03-30 microM, IC-50 = 0.5 microM) without affecting MAO A activity. Considering the alleged contribution of MAO activity in general, and MAO-B in particular, to oxidative stress and neurodegeneration in PD, our data further support the neuroprotective potential of ADT.

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Year:  2005        PMID： 16252076     DOI： 10.1007/s00702-005-0350-0

Source DB:  PubMed          Journal:  J Neural Transm (Vienna)        ISSN： 0300-9564            Impact factor:   3.575


  20 in total

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Authors:  B Drukarch; E Schepens; J C Stoof; C H Langeveld
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4.  mTOR and ROS regulation by anethole on adipogenic differentiation in human mesenchymal stem cells.

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5.  Therapeutic effect of hydrogen sulfide-releasing L-Dopa derivative ACS84 on 6-OHDA-induced Parkinson's disease rat model.

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6.  Evaluation of antidepressant-like effects of aqueous and ethanolic extracts of Pimpinella anisum fruit in mice.

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  6 in total

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