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Literature DB >> 16251329

Differential antibiotic susceptibilities of starved Mycobacterium tuberculosis isolates.

Zhifang Xie¹, Noman Siddiqi, Eric J Rubin.

Abstract

We compared the efficacies of 17 agents against rapidly growing and starved Mycobacterium tuberculosis H37Rv. Few compounds have significant activity at attainable concentrations. However, two phenothiazine compounds at similar concentrations were bactericidal for starved and growing cells. These drugs appear to target a process important in both replicating and nonreplicating bacteria.

Entities: Chemical Species

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Year: 2005 PMID： 16251329 PMCID： PMC1280169 DOI： 10.1128/AAC.49.11.4778-4780.2005

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

16 in total

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66 in total

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Journal: Chem Biol Date: 2013-03-21

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Authors: Jansy Sarathy; Véronique Dartois; Thomas Dick; Martin Gengenbacher
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