| Literature DB >> 16250900 |
Abstract
Misfolded endoplasmic reticulum (ER) proteins are eliminated by the retrotranslocation pathway in eukaryotes, which is an important physiological adaptation to ER stress. This pathway can be hijacked by certain viruses to destroy folded cellular proteins, such as MHC class I heavy chain. Recent studies have highlighted the importance of the ubiquitin-proteasome system (UPS) in this process.Mesh:
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Year: 2005 PMID: 16250900 DOI: 10.1042/EB0410099
Source DB: PubMed Journal: Essays Biochem ISSN: 0071-1365 Impact factor: 8.000