Literature DB >> 16250833

Advances in prodrug design.

Antonio Távora de Albuquerque Silva1, Man Chin Chung, Lúcia Fioravanti Castro, Rafael Victorio Carvalho Güido, Elizabeth Igne Ferreira.   

Abstract

The background of prodrug design is presented herein as the basis for introducing new and advanced latent systems, taking into account mainly the versatility of polymers and other macromolecules as carriers. PDEPT (Polymer-Directed Enzyme Prodrug Therapy); PELT (Polymer-Enzyme Liposome Therapy); CDS (Chemical Delivery System); ADEPT(Antibody-Directed Enzyme Prodrug Therapy); GDEPT/VDEPT (Gene-Directed Enzyme Prodrug Therapy/Virus-Directed Enzyme Prodrug Therapy); ODDS (Osteotropic Drug Delivery System) and LEAPT (Lectin-directed enzyme-activated prodrug therapy) are briefly described and some examples are given.

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Year:  2005        PMID： 16250833     DOI： 10.2174/138955705774329528

Source DB:  PubMed          Journal:  Mini Rev Med Chem        ISSN： 1389-5575            Impact factor:   3.862


  14 in total

1.  Design and exploratory data analysis of a second generation of dendrimer prodrugs potentially antichagasic and leishmanicide.

Authors:  Jeanine Giarolla; Kerly Fernanda Mesquita Pasqualoto; Elizabeth I Ferreira
Journal:  Mol Divers       Date:  2013-08-29       Impact factor: 2.943

Review 2.  Prodrug applications for targeted cancer therapy.

Authors:  Irene Giang; Erin L Boland; Gregory M K Poon
Journal:  AAPS J       Date:  2014-07-09       Impact factor: 4.009

3.  Hydroxymethylnitrofurazone is active in a murine model of Chagas' disease.

Authors:  Carolina Davies; Rubén Marino Cardozo; Olga Sánchez Negrette; María Celia Mora; Man Chin Chung; Miguel Angel Basombrío
Journal:  Antimicrob Agents Chemother       Date:  2010-06-21       Impact factor: 5.191

Review 4.  Recent trends in targeted anticancer prodrug and conjugate design.

Authors:  Yashveer Singh; Matthew Palombo; Patrick J Sinko
Journal:  Curr Med Chem       Date:  2008       Impact factor: 4.530

Review 5.  Positron emission tomography image-guided drug delivery: current status and future perspectives.

Authors:  Rubel Chakravarty; Hao Hong; Weibo Cai
Journal:  Mol Pharm       Date:  2014-06-04       Impact factor: 4.939

6.  Synthesis, characterization and pharmacological evaluation of 1-(2-chloro-6-fluorophenyl)-5-methylindolin-2-one: a new anti-inflammatory compound with reduced gastric ulceration properties.

Authors:  Jean Leandro dos Santos; Rafael Chelucci; Richard Chiquetto; Man Chin Chung; Michel Leandro Campos; Rosangela Gonçalves Peccinini
Journal:  Molecules       Date:  2010-11-08       Impact factor: 4.411

7.  Screening Analogs of β-OG Pocket Binder as Fusion Inhibitor of Dengue Virus 2.

Authors:  Usman Sf Tambunan; Hilyatuz Zahroh; Arli A Parikesit; Syarifuddin Idrus; Djati Kerami
Journal:  Drug Target Insights       Date:  2015-11-16

8.  Utilization of Boron Compounds for the Modification of Suberoyl Anilide Hydroxamic Acid as Inhibitor of Histone Deacetylase Class II Homo sapiens.

Authors:  Ridla Bakri; Arli Aditya Parikesit; Cipta Prio Satriyanto; Djati Kerami; Usman Sumo Friend Tambunan
Journal:  Adv Bioinformatics       Date:  2014-08-24

9.  Synthesis, ex vivo and in vitro hydrolysis study of an indoline derivative designed as an anti-inflammatory with reduced gastric ulceration properties.

Authors:  Man Chin Chung; Jean Leandro dos Santos; Ednir Vizioli Oliveira; Lorena Blau; Renato Farina Menegon; Rosângela Gonçalves Peccinini
Journal:  Molecules       Date:  2009-08-26       Impact factor: 4.411

Review 10.  Prodrugs in cardiovascular therapy.

Authors:  Marinella G Sandros; Chady B Sarraf; Maryam Tabrizian
Journal:  Molecules       Date:  2008-05-14       Impact factor: 4.411
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