Literature DB >> 16250632

Design and synthesis of peptidomimetic severe acute respiratory syndrome chymotrypsin-like protease inhibitors.

Arun K Ghosh1, Kai Xi, Kiira Ratia, Bernard D Santarsiero, Wentao Fu, Brian H Harcourt, Paul A Rota, Susan C Baker, Michael E Johnson, Andrew D Mesecar.   

Abstract

Design, synthesis, and biological evaluation of peptidomimetic severe acute respiratory syndrome chymotrypsin-like protease (SARS-3CLpro) inhibitors for severe acute respiratory syndrome coronavirus (SARS-CoV) are described. These inhibitors exhibited antiviral activity against SARS-CoV in infected cells in the micromolar range. An X-ray crystal structure of our lead inhibitor (4) bound to SARS-3CLpro provided important drug-design templates for the design of small-molecule inhibitors.

Entities:  

Mesh：

Substances：

Year:  2005        PMID： 16250632     DOI： 10.1021/jm050548m

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  62 in total

1.  Severe acute respiratory syndrome coronavirus papain-like protease: structure of a viral deubiquitinating enzyme.

Authors:  Kiira Ratia; Kumar Singh Saikatendu; Bernard D Santarsiero; Naina Barretto; Susan C Baker; Raymond C Stevens; Andrew D Mesecar
Journal:  Proc Natl Acad Sci U S A       Date:  2006-03-31       Impact factor: 11.205

2.  Inhibitors of SARS-3CLpro: virtual screening, biological evaluation, and molecular dynamics simulation studies.

Authors:  Prasenjit Mukherjee; Falgun Shah; Prashant Desai; Mitchell Avery
Journal:  J Chem Inf Model       Date:  2011-05-23       Impact factor: 4.956

3.  Discovery, synthesis, and structure-based optimization of a series of N-(tert-butyl)-2-(N-arylamido)-2-(pyridin-3-yl) acetamides (ML188) as potent noncovalent small molecule inhibitors of the severe acute respiratory syndrome coronavirus (SARS-CoV) 3CL protease.

Authors:  Jon Jacobs; Valerie Grum-Tokars; Ya Zhou; Mark Turlington; S Adrian Saldanha; Peter Chase; Aimee Eggler; Eric S Dawson; Yahira M Baez-Santos; Sakshi Tomar; Anna M Mielech; Susan C Baker; Craig W Lindsley; Peter Hodder; Andrew Mesecar; Shaun R Stauffer
Journal:  J Med Chem       Date:  2013-01-03       Impact factor: 7.446

4.  Pyrrole-based scaffolds for turn mimics.

Authors:  Eunhwa Ko; Kevin Burgess
Journal:  Org Lett       Date:  2011-01-26       Impact factor: 6.005

5.  Long-range cooperative interactions modulate dimerization in SARS 3CLpro.

Authors:  Jennifer Barrila; Usman Bacha; Ernesto Freire
Journal:  Biochemistry       Date:  2006-12-19       Impact factor: 3.162

6.  A novel mutation in murine hepatitis virus nsp5, the viral 3C-like proteinase, causes temperature-sensitive defects in viral growth and protein processing.

Authors:  Jennifer S Sparks; Eric F Donaldson; Xiaotao Lu; Ralph S Baric; Mark R Denison
Journal:  J Virol       Date:  2008-04-02       Impact factor: 5.103

7.  Proteolytic processing and deubiquitinating activity of papain-like proteases of human coronavirus NL63.

Authors:  Zhongbin Chen; Yanhua Wang; Kiira Ratia; Andrew D Mesecar; Keith D Wilkinson; Susan C Baker
Journal:  J Virol       Date:  2007-03-28       Impact factor: 5.103

8.  Coronaviruses resistant to a 3C-like protease inhibitor are attenuated for replication and pathogenesis, revealing a low genetic barrier but high fitness cost of resistance.

Authors:  Xufang Deng; Sarah E StJohn; Heather L Osswald; Amornrat O'Brien; Bridget S Banach; Katrina Sleeman; Arun K Ghosh; Andrew D Mesecar; Susan C Baker
Journal:  J Virol       Date:  2014-08-06       Impact factor: 5.103

Review 9.  Severe acute respiratory syndrome coronavirus as an agent of emerging and reemerging infection.

Authors:  Vincent C C Cheng; Susanna K P Lau; Patrick C Y Woo; Kwok Yung Yuen
Journal:  Clin Microbiol Rev       Date:  2007-10       Impact factor: 26.132

10.  Progress in Anti-SARS Coronavirus Chemistry, Biology and Chemotherapy.

Authors:  Arun K Ghosh; Kai Xi; Michael E Johnson; Susan C Baker; Andrew D Mesecar
Journal:  Annu Rep Med Chem       Date:  2007-02-01       Impact factor: 1.059
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.