| Literature DB >> 16248640 |
K C Nicolaou1, Mark Zak, Shai Rahimipour, Anthony A Estrada, Sang Hyup Lee, Aurora O'Brate, Paraskevi Giannakakou, M Reza Ghadiri.
Abstract
Design, synthesis, and biological evaluation of several domains of the thiopeptide antibiotic thiostrepton led to the discovery of a biologically active fragment. The biological properties of this novel small organic molecule include antibiotic activity against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecalis (VREF) bacterial strains, as well as cytotoxic action against a number of cancer cell lines.Entities:
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Year: 2005 PMID： 16248640 DOI： 10.1021/ja0552803
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419