Literature DB >> 16247982

Novel cyclosal nucleotides with reduced inhibitory potency toward human butyrylcholinesterase.

C Ducho1, S Jessel, N Gisch, J Balzarini, C Meier.   

Abstract

Two novel cycloSal-d4T monophosphates (d4TMPs) with increased steric demand have been synthesized via a new synthetic route. While 3-cyclohexyl-cycloSal d4TMP did not show a significantly reduced inhibitory potency toward human butyrylcholinesterase, the opposite was the case for the second novel pronucleotide, bis-(cycloSal-d4TMP).

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Year:  2005        PMID: 16247982     DOI: 10.1081/ncn-200061791

Source DB:  PubMed          Journal:  Nucleosides Nucleotides Nucleic Acids        ISSN: 1525-7770            Impact factor:   1.381


  1 in total

Review 1.  Prodrug approaches to improving the oral absorption of antiviral nucleotide analogues.

Authors:  Larryn W Peterson; Charles E McKenna
Journal:  Expert Opin Drug Deliv       Date:  2009-04       Impact factor: 6.648

  1 in total

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