Literature DB >> 16247440

Outlook: the profit problem in antibiotic R&D.

Carl Nathan1, Frederick M Goldberg.   

Abstract

Economists, a biomedical researcher and a business executive have formulated three contrasting proposals to address the shortfall in antibiotic R&D. Their proposals, which emphasize advance purchase contracts, not-for-profit research, and tax incentives, respectively, share some features with provisions in bills pending before the US Congress that could potentially reshape the R&D landscape for this essential class of drugs.

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Year:  2005        PMID: 16247440     DOI: 10.1038/nrd1878

Source DB:  PubMed          Journal:  Nat Rev Drug Discov        ISSN: 1474-1776            Impact factor:   84.694


  11 in total

1.  Microbes have the last word. A drastic re-evaluation of antimicrobial treatment is needed to overcome the threat of antibiotic-resistant bacteria.

Authors:  Julian Davies
Journal:  EMBO Rep       Date:  2007-07       Impact factor: 8.807

2.  Public funding of clinical-stage antibiotic development in the United States and European Union.

Authors:  Michael J Eichberg
Journal:  Health Secur       Date:  2015 May-Jun

Review 3.  Bacterial resistance: a sensitive issue complexity of the challenge and containment strategy in Europe.

Authors:  W T M Jansen; J T van der Bruggen; J Verhoef; A C Fluit
Journal:  Drug Resist Updat       Date:  2006-06-27       Impact factor: 18.500

4.  Recombinant Expression of a Putative Amidase Cloned from the Genome of Listeria monocytogenes that Lyses the Bacterium and its Monolayer in Conjunction with a Protease.

Authors:  Mustafa Simmons; Cesar A Morales; Brian B Oakley; Bruce S Seal
Journal:  Probiotics Antimicrob Proteins       Date:  2012-03       Impact factor: 4.609

5.  Isolation of Lactobacillus salivarius 1077 (NRRL B-50053) and characterization of its bacteriocin, including the antimicrobial activity spectrum.

Authors:  Edward A Svetoch; Boris V Eruslanov; Vladimir P Levchuk; Vladimir V Perelygin; Evgeny V Mitsevich; Irina P Mitsevich; Juri Stepanshin; Ivan Dyatlov; Bruce S Seal; Norman J Stern
Journal:  Appl Environ Microbiol       Date:  2011-03-04       Impact factor: 4.792

Review 6.  Antibiotics for emerging pathogens.

Authors:  Michael A Fischbach; Christopher T Walsh
Journal:  Science       Date:  2009-08-28       Impact factor: 47.728

7.  Design and Synthesis of Molecular Scaffolds with Anti-infective Activity.

Authors:  Junjia Liu; T Aaron Bedell; Julian G West; Erik J Sorensen
Journal:  Tetrahedron       Date:  2016-01-28       Impact factor: 2.457

8.  Response of Staphylococcus aureus to subinhibitory concentrations of a sequence-selective, DNA minor groove cross-linking pyrrolobenzodiazepine dimer.

Authors:  Marie Doyle; Eva-Anne Feuerbaum; Keith R Fox; Jason Hinds; David E Thurston; Peter W Taylor
Journal:  J Antimicrob Chemother       Date:  2009-09-10       Impact factor: 5.790

9.  Phage therapy: concept to cure.

Authors:  Eric C Keen
Journal:  Front Microbiol       Date:  2012-07-19       Impact factor: 5.640

10.  Purification and characterization of a novel lipopeptide from Streptomyces amritsarensis sp. nov. active against methicillin-resistant Staphylococcus aureus.

Authors:  Deepika Sharma; Santi M Mandal; Rajesh Kumari Manhas
Journal:  AMB Express       Date:  2014-06-28       Impact factor: 3.298

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