Literature DB >> 16246616

Immunohistochemical analysis of P57(kip2), p53 and hsp60 expressions in premalignant and malignant oral tissues.

Guo-Kang Fan1, Jun Chen, Feiyun Ping, Yanhua Geng.   

Abstract

To investigate the expressions and significances of P57(kip2), p53 and hsp60 proteins in the dysplasia-carcinoma sequence of oral mucosa. A retrospective study was performed in 10 cases of normal oral mucosa, 79 cases of leukoplakia and 67 cases of squamous cell carcinoma (SCC). The expressions of P57(kip2), p53 and hsp60 proteins were detected in the tissue samples of these populations using immunohistochemical method. P57(kip2) expression was decreased in oral leukoplakia with moderate or severe dysplasia, and further decreased in oral SCC. Negative expression of P57(kip2) was significantly associated with advanced tumor size, the occurrence of lymph node metastasis and the advanced clinical stage in oral SCC. The overall 5-year survival rate in the P57(kip2) positive group was significantly higher than that in the P57(kip2) negative group. P57(kip2) expression was decreased in oral leukoplakia with moderate or severe dysplasia, and further decreased in oral SCC. It was a remarkable progressive and prognostic biomarker in oral SCC.

Entities:  

Mesh：

Substances：

Year:  2005        PMID： 16246616     DOI： 10.1016/j.oraloncology.2005.06.017

Source DB:  PubMed          Journal:  Oral Oncol        ISSN： 1368-8375            Impact factor:   5.337


  8 in total

1.  Incorporation of histone deacetylase inhibition into the structure of a nuclear receptor agonist.

Authors:  Luz E Tavera-Mendoza; Tan D Quach; Basel Dabbas; Jonathan Hudon; Xiaohong Liao; Ana Palijan; James L Gleason; John H White
Journal:  Proc Natl Acad Sci U S A       Date:  2008-06-12       Impact factor: 11.205

2.  Exploiting the HSP60/10 chaperonin system as a chemotherapeutic target for colorectal cancer.

Authors:  Anne-Marie Ray; Nilshad Salim; Mckayla Stevens; Siddhi Chitre; Sanofar Abdeen; Alex Washburn; Jared Sivinski; Heather M O'Hagan; Eli Chapman; Steven M Johnson
Journal:  Bioorg Med Chem       Date:  2021-04-19       Impact factor: 3.461

3.  p27Kip1 expression as a prognostic marker for squamous cell carcinoma of the head and neck.

Authors:  Miguel Reis DE Almeida; Mario Pérez-Sayáns; José Manuel Suárez-Peñaranda; José Manuel Somoza-Martín; Abel García-García
Journal:  Oncol Lett       Date:  2015-09-18       Impact factor: 2.967

4.  Correlation of p53 Expression with Histopathological and Immunohistochemical Features of Human Papillomavirus in Oral Leukoplakia.

Authors:  Dhirendra Gururaj Sirur; Avinash Tamgadge; Sandhya Tamgadge; Sudhir Bhalerao; Pavan Kumar Gujjar
Journal:  J Microsc Ultrastruct       Date:  2020-09-10

5.  Expression of p15INK⁴b and p57KIP² and relationship with clinicopathological features and prognosis in patients with vulvar squamous cell carcinoma.

Authors:  Ruth Holm; Mette Førsund; Mai T Nguyen; Jahn M Nesland; Claes G Trope
Journal:  PLoS One       Date:  2013-04-08       Impact factor: 3.240

6.  CDKN1C/p57kip2 is a candidate tumor suppressor gene in human breast cancer.

Authors:  Pamela S Larson; Benjamin L Schlechter; Chia-Lin King; Qiong Yang; Chelsea N Glass; Charline Mack; Robert Pistey; Antonio de Las Morenas; Carol L Rosenberg
Journal:  BMC Cancer       Date:  2008-03-06       Impact factor: 4.430

7.  Expression of survivin and p53 in oral lichen planus, lichenoid reaction and lichenoid dysplasia: An immunohistochemical study.

Authors:  Shaini Basheer; P M Shameena; S Sudha; Sujatha Varma; S Vidyanath; Aniruddha Varekar
Journal:  J Oral Maxillofac Pathol       Date:  2017 Sep-Dec

8.  Correlation of CA19-9 and P57 (KiP2) Expression with Tumor Grade and Invasive Front in Oral Squamous Cell Carcinoma.

Authors:  Fatemeh Mashhadiabbas; Moones Rajabi; Mohammad Javad KharaziFard; Hamidreza Moslemi
Journal:  J Dent (Shiraz)       Date:  2018-12
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.