Jodi B Segal1, Alison R Moliterno. 1. Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. jsegal@jhmi.edu
Abstract
PURPOSE: The aim of the study is to show that differences in platelet counts by ethnicity, sex, and age are not explained by environmental factors. METHODS: This is a cross-sectional population-based study of participants in the Third National Health and Nutrition Examination Survey. Our analytic sample included 12,142 participants, of whom 65% were women, 27% were non-Hispanic blacks, and 27% were Mexican Americans. We report weighted geometric mean platelet counts stratified by ethnicity, sex, and age and controlled for indicators of nutritional deficiencies and inflammation. RESULTS: The lowest mean platelet counts were in whites (260x10(3)/microL; 95% confidence interval [CI], 256-264), and the highest were in non-Hispanic blacks (281x10(3)/microL [95% CI, 276-286]). Older men and women of each ethnicity consistently had lower platelet counts than young adults; 60- to 69-year-olds had mean counts 7x10(3)/microL lower (p<0.001) and 70- to 90-year-olds had counts 18x10(3)/microL lower (p<0.001). Even controlling for iron deficiency, women had higher platelet counts than men (275x10(3)/microL; 95% CI, 271-279) versus 256x10(3)/microL (95% CI, 251-260; p<0.001). CONCLUSIONS: Platelet count differences by sex, ethnicity, and age are not explained by environmental covariates known to influence platelet count.
PURPOSE: The aim of the study is to show that differences in platelet counts by ethnicity, sex, and age are not explained by environmental factors. METHODS: This is a cross-sectional population-based study of participants in the Third National Health and Nutrition Examination Survey. Our analytic sample included 12,142 participants, of whom 65% were women, 27% were non-Hispanic blacks, and 27% were Mexican Americans. We report weighted geometric mean platelet counts stratified by ethnicity, sex, and age and controlled for indicators of nutritional deficiencies and inflammation. RESULTS: The lowest mean platelet counts were in whites (260x10(3)/microL; 95% confidence interval [CI], 256-264), and the highest were in non-Hispanic blacks (281x10(3)/microL [95% CI, 276-286]). Older men and women of each ethnicity consistently had lower platelet counts than young adults; 60- to 69-year-olds had mean counts 7x10(3)/microL lower (p<0.001) and 70- to 90-year-olds had counts 18x10(3)/microL lower (p<0.001). Even controlling for iron deficiency, women had higher platelet counts than men (275x10(3)/microL; 95% CI, 271-279) versus 256x10(3)/microL (95% CI, 251-260; p<0.001). CONCLUSIONS: Platelet count differences by sex, ethnicity, and age are not explained by environmental covariates known to influence platelet count.
Authors: Ursula M Schick; Deepti Jain; Chani J Hodonsky; Jean V Morrison; James P Davis; Lisa Brown; Tamar Sofer; Matthew P Conomos; Claudia Schurmann; Caitlin P McHugh; Sarah C Nelson; Swarooparani Vadlamudi; Adrienne Stilp; Anna Plantinga; Leslie Baier; Stephanie A Bien; Stephanie M Gogarten; Cecelia A Laurie; Kent D Taylor; Yongmei Liu; Paul L Auer; Nora Franceschini; Adam Szpiro; Ken Rice; Kathleen F Kerr; Jerome I Rotter; Robert L Hanson; George Papanicolaou; Stephen S Rich; Ruth J F Loos; Brian L Browning; Sharon R Browning; Bruce S Weir; Cathy C Laurie; Karen L Mohlke; Kari E North; Timothy A Thornton; Alex P Reiner Journal: Am J Hum Genet Date: 2016-01-21 Impact factor: 11.025
Authors: Kristin Wallace; Hong Li; J Grant Brazeal; David N Lewin; Shaoli Sun; Aissatou Ba; Chrystal M Paulos; Saleh Rachidi; Zihai Li; Alexander V Alekseyenko Journal: Cancer Epidemiol Date: 2020-06-07 Impact factor: 2.984
Authors: Stephen C Gale; Li Gao; Carmen Mikacenic; Susette M Coyle; Nicholas Rafaels; Tanda Murray Dudenkov; Jennifer H Madenspacher; David W Draper; William Ge; Jim J Aloor; Kathleen M Azzam; Lihua Lai; Perry J Blackshear; Steven E Calvano; Kathleen C Barnes; Stephen F Lowry; Siobhan Corbett; Mark M Wurfel; Michael B Fessler Journal: J Allergy Clin Immunol Date: 2014-03-18 Impact factor: 10.793
Authors: Miklos Z Molnar; Elani Streja; Csaba P Kovesdy; Matthew J Budoff; Allen R Nissenson; Mahesh Krishnan; Stefan D Anker; Keith C Norris; Gregg C Fonarow; Kamyar Kalantar-Zadeh Journal: Am J Clin Nutr Date: 2011-08-03 Impact factor: 7.045
Authors: Juha J Hulmi; T Myllymäki; M Tenhumäki; N Mutanen; R Puurtinen; G Paulsen; A A Mero Journal: Eur J Appl Physiol Date: 2010-01-26 Impact factor: 3.078